AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

por Hettinger, Jane C., Lee, Hyo, Bu, Guojun, Holtzman, David M., Cirrito, John R.
Publicado 2018

Redundant G(s)-coupled serotonin receptors regulate amyloid-β metabolism in vivo

por Fisher, Jonathan R., Wallace, Clare E., Tripoli, Danielle L., Sheline, Yvette I., Cirrito, John R.
Publicado 2016

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease

por Thomas, Riya, Zimmerman, Scott D., Yuede, Kayla M., Cirrito, John R., Tai, Leon M., Timson, Benjamin F., Yuede, Carla M.
Publicado 2020

Characterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

por Sundaram, G.S.M., Garai, Kanchan, Rath, Nigam P., Yan, Ping, Cirrito, John R., Cairns, Nigel J., Lee, Jin-Moo, Sharma, Vijay
Publicado 2014

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

por Bero, Adam W., Yan, Ping, Roh, Jee Hoon, Cirrito, John R., Stewart, Floy R., Raichle, Marcus E., Lee, Jin-Moo, Holtzman, David M.
Publicado 2011

Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice

por Chiang, Angie C.A., Fowler, Stephanie W., Savjani, Ricky R., Hilsenbeck, Susan G., Wallace, Clare E., Cirrito, John R., Das, Pritam, Jankowsky, Joanna L.
Publicado 2018

Interactions between stress and physical activity on Alzheimer's disease pathology

por Yuede, Carla M., Timson, Benjamin F., Hettinger, Jane C., Yuede, Kayla M., Edwards, Hannah M., Lawson, Justin E., Zimmerman, Scott D., Cirrito, John R.
Publicado 2018

Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model

por Cirrito, John R., Wallace, Clare E., Yan, Ping, Davis, Todd A., Gardiner, Woodrow D., Doherty, Brookelyn M., King, Diana, Yuede, Carla M., Lee, Jin-Moo, Sheline, Yvette I.
Publicado 2020

Neuronal activity regulates extracellular tau in vivo

por Yamada, Kaoru, Holth, Jerrah K., Liao, Fan, Stewart, Floy R., Mahan, Thomas E., Jiang, Hong, Cirrito, John R., Patel, Tirth K., Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M.
Publicado 2014

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

por Yuede, Carla M., Lee, Hyo, Restivo, Jessica L., Davis, Todd A., Hettinger, Jane C., Wallace, Clare E., Young, Katherine L., Hayne, Margaret R., Bu, Guojun, Li, Chen-zhong, Cirrito, John R.
Publicado 2016

ApoE mimetic peptide decreases Aβ production in vitro and in vivo

por Minami, S Sakura, Cordova, Antoinette, Cirrito, John R, Tesoriero, Joseph A, Babus, Lenard W, Davis, Gary C, Dakshanamurthy, Sivanesan, Turner, R Scott, Pak, Daniel TS, Rebeck, G William, Paige, Mikell, Hoe, Hyang-Sook
Publicado 2010

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

por Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M
Publicado 2013

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

por Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R., Mahan, Thomas E., Cirrito, John R., Heda, Ashish, Snider, B. Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M.
Publicado 2014

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

por Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R., Mahan, Thomas E., Cirrito, John R., Heda, Ashish, Snider, B. Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M.
Publicado 2015

TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model

por Wang, Yaming, Cella, Marina, Mallinson, Kaitlin, Ulrich, Jason D., Young, Katherine L., Robinette, Michelle L., Gifillian, Susan, Krishnan, Gokul M., Sudhakar, Shwetha, Zinselmeyer, Bernd H., Holtzman, David M., Cirrito, John R., Colonna, Marco
Publicado 2015

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

por Steele, John W, Kim, Soong H, Cirrito, John R, Verges, Deborah K, Restivo, Jessica L, Westaway, David, Fraser, Paul, Hyslop, Peter St George, Sano, Mary, Bezprozvanny, Ilya, Ehrlich, Michelle E, Holtzman, David M, Gandy, Sam
Publicado 2009

Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia

por Miller, Rebecca L., Dhavale, Dhruva D., O’Shea, Jennifer Y., Andruska, Kristin M., Liu, Jialu, Franklin, Erin E., Buddhala, Chandana, Loftin, Susan K., Cirrito, John R., Perrin, Richard J., Cairns, Nigel J., Campbell, Meghan C., Perlmutter, Joel S., Kotzbauer, Paul T.
Publicado 2022

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

por Stukas, Sophie, Robert, Jerome, Lee, Michael, Kulic, Iva, Carr, Michael, Tourigny, Katherine, Fan, Jianjia, Namjoshi, Dhananjay, Lemke, Kalistyne, DeValle, Nicole, Chan, Jeniffer, Wilson, Tammy, Wilkinson, Anna, Chapanian, Rafi, Kizhakkedathu, Jayachandran N., Cirrito, John R., Oda, Michael N., Wellington, Cheryl L.
Publicado 2014

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

por Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
Publicado 2016

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

por Czirr, Eva, Castello, Nicholas A., Mosher, Kira I., Castellano, Joseph M., Hinkson, Izumi V., Lucin, Kurt M., Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N., Belichenko, Nadia P., Longo, Frank M., Akassoglou, Katerina, Britschgi, Markus, Cirrito, John R., Wyss-Coray, Tony
Publicado 2017