Rapid therapeutic advances in CFTR modulator science

por Clancy, John P.
Publicado 2018

Flexible semiparametric joint modeling: an application to estimate individual lung function decline and risk of pulmonary exacerbations in cystic fibrosis

por Li, Dan, Keogh, Ruth, Clancy, John P., Szczesniak, Rhonda D.
Publicado 2017

CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity

por Kramer, Elizabeth L., Hudock, Kristin M., Davidson, Cynthia R., Clancy, John P.
Publicado 2023

An Animated Functional Data Analysis Interface to Cluster Rapid Lung Function Decline and Enhance Center-Level Care in Cystic Fibrosis

por Pratt, Jesse, Su, Weiji, Hayes, Don, Clancy, John P., Szczesniak, Rhonda D.
Publicado 2021

2045 The role of TGFβ in driving early cystic fibrosis lung disease

por Kramer, Elizabeth L., Hardie, William, Hudock, Kristin, Davidson, Cynthia, Ostmann, Alicia, Clancy, John P.
Publicado 2018

Phenotypic Alteration of an Established Human Airway Cell Line by Media Selection

por Livnat, Galit, Meeker, Jessica D., Ostmann, Alicia J., Strecker, Lauren M., Clancy, John P., Brewington, John J.
Publicado 2023

3123 TGFbeta, Early Cytokine Dysregulation, and Airway Smooth Muscle Dysfunction in Cystic Fibrosis

por Kramer, Elizabeth L, Szczesniak, Rhonda, Su, Weiji, Madala, Satish, Hudock, Kristin, Davidson, Cynthia, Ostmann, Alicia, Strecker, Lauren, Clancy, John P.
Publicado 2019

Dynamic predictive probabilities to monitor rapid cystic fibrosis disease progression

por Szczesniak, Rhonda D., Su, Weiji, Brokamp, Cole, Keogh, Ruth H., Pestian, John P., Seid, Michael, Diggle, Peter J., Clancy, John P.
Publicado 2019

Data driven decision making to characterize clinical personas of parents of children with cystic fibrosis: a mixed methods study

por Szczesniak, Rhonda D., Pestian, Teresa, Duan, Leo L., Li, Dan, Stamper, Sophia, Ferrara, Brycen, Kramer, Elizabeth, Clancy, John P., Grossoehme, Daniel
Publicado 2020

TGF-Beta Downregulation of Distinct Chloride Channels in Cystic Fibrosis-Affected Epithelia

por Sun, Hongtao, Harris, William T., Kortyka, Stephanie, Kotha, Kavitha, Ostmann, Alicia J., Rezayat, Amir, Sridharan, Anusha, Sanders, Yan, Naren, Anjaparavanda P., Clancy, John P.
Publicado 2014

CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions

por Stuart, William D, Guo, Minzhe, Fink-Baldauf, Iris M, Coleman, Alan M, Clancy, John P, Mall, Marcus A, Lim, Foong-Yen, Brewington, John J, Maeda, Yutaka
Publicado 2020

Seasonality, mediation and comparison (SMAC) methods to identify influences on lung function decline

por Gecili, Emrah, Palipana, Anushka, Brokamp, Cole, Huang, Rui, Andrinopoulou, Eleni-Rosalina, Pestian, Teresa, Rasnick, Erika, Keogh, Ruth H., Ni, Yizhao, Clancy, John P., Ryan, Patrick, Szczesniak, Rhonda D.
Publicado 2021

Optimizing Nasal Potential Difference Analysis for CFTR Modulator Development: Assessment of Ivacaftor in CF Subjects with the G551D-CFTR Mutation

por Rowe, Steven M., Liu, Bo, Hill, Aubrey, Hathorne, Heather, Cohen, Morty, Beamer, John R., Accurso, Frank J., Dong, Qunming, Ordoñez, Claudia L., Stone, Anne J., Olson, Eric R., Clancy, John P.
Publicado 2013

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

por Nichols, David P., Morgan, Sarah J., Skalland, Michelle, Vo, Anh T., Van Dalfsen, Jill M., Singh, Sachinkumar B.P., Ni, Wendy, Hoffman, Lucas R., McGeer, Kailee, Heltshe, Sonya L., Clancy, John P., Rowe, Steven M., Jorth, Peter, Singh, Pradeep K.
Publicado 2023

Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis

por Sermet-Gaudelus, Isabelle, Clancy, John P., Nichols, David P., Nick, Jerry A., De Boeck, Kris, Solomon, George M., Mall, Marcus A., Bolognese, James, Bouisset, Florilene, den Hollander, Wilhelmina, Paquette-Lamontagne, Nicolas, Tomkinson, Nigel, Henig, Noreen, Elborn, J. Stuart, Rowe, Steven M.
Publicado 2018

Evaluating the Impact of Stopping Chronic Therapies after Modulator Drug Therapy in Cystic Fibrosis: The SIMPLIFY Clinical Trial Study Design

por Mayer-Hamblett, Nicole, Nichols, David P., Odem-Davis, Katherine, Riekert, Kristin A., Sawicki, Greg S., Donaldson, Scott H., Ratjen, Felix, Konstan, Michael W., Simon, Noah, Rosenbluth, Daniel B., Retsch-Bogart, George, Clancy, John P., VanDalfsen, Jill M., Buckingham, Rachael, Gifford, Alex H.
Publicado 2021

Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function

por Clancy, John P., Szczesniak, Rhonda D., Ashlock, Melissa A., Ernst, Sarah E., Fan, Lijuan, Hornick, Douglas B., Karp, Philip H., Khan, Umer, Lymp, James, Ostmann, Alicia J., Rezayat, Amir, Starner, Timothy D., Sugandha, Shajan P., Sun, Hongtao, Quinney, Nancy, Donaldson, Scott H., Rowe, Steven M., Gabriel, Sherif E.
Publicado 2013

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis

por Gardner, Aaron I., Haq, Iram J., Simpson, A. John, Becker, Katrin A., Gallagher, John, Saint-Criq, Vinciane, Verdon, Bernard, Mavin, Emily, Trigg, Alexandra, Gray, Michael A., Koulman, Albert, McDonnell, Melissa J., Fisher, Andrew J., Kramer, Elizabeth L., Clancy, John P., Ward, Christopher, Schuchman, Edward H., Gulbins, Erich, Brodlie, Malcolm
Publicado 2020

Cystic Fibrosis–Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes

por Putman, Melissa S., Norris, Andrew W., Hull, Rebecca L., Rickels, Michael R., Sussel, Lori, Blackman, Scott M., Chan, Christine L., Ode, Katie Larson, Daley, Tanicia, Stecenko, Arlene A., Moran, Antoinette, Helmick, Meagan J., Cray, Sharon, Alvarez, Jessica A., Stallings, Virginia A., Tuggle, Katherine L., Clancy, John P., Eggerman, Thomas L., Engelhardt, John F., Kelly, Andrea
Publicado 2023

Cystic Fibrosis–Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes

por Putman, Melissa S., Norris, Andrew W., Hull, Rebecca L., Rickels, Michael R., Sussel, Lori, Blackman, Scott M., Chan, Christine L., Ode, Katie Larson, Daley, Tanicia, Stecenko, Arlene A., Moran, Antoinette, Helmick, Meagan J., Cray, Sharon, Alvarez, Jessica A., Stallings, Virginia A., Tuggle, Katherine L., Clancy, John P., Eggerman, Thomas L., Engelhardt, John F., Kelly, Andrea
Publicado 2023