An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

por Patel, Rohit N., Clare, Rachel H., Ledsgaard, Line, Nys, Mieke, Kool, Jeroen, Laustsen, Andreas H., Ulens, Chris, Casewell, Nicholas R.
Publicado 2023

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

por Gutiérrez, José María, Albulescu, Laura-Oana, Clare, Rachel H., Casewell, Nicholas R., Abd El-Aziz, Tarek Mohamed, Escalante, Teresa, Rucavado, Alexandra
Publicado 2021

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

por Menzies, Stefanie K., Clare, Rachel H., Xie, Chunfang, Westhorpe, Adam, Hall, Steven R., Edge, Rebecca J., Alsolaiss, Jaffer, Crittenden, Edouard, Marriott, Amy E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Publicado 2022

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library

por Johnston, Kelly L., Cook, Darren A. N., Berry, Neil G., David Hong, W., Clare, Rachel H., Goddard, Megan, Ford, Louise, Nixon, Gemma L., O’Neill, Paul M., Ward, Stephen A., Taylor, Mark J.
Publicado 2017

Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership

por Clare, Rachel H., Clark, Roger, Bardelle, Catherine, Harper, Paul, Collier, Matthew, Johnston, Kelly L., Plant, Helen, Plant, Darren, McCall, Eileen, Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Ford, Louise, Murray, David, Rich, Kirsty, Wigglesworth, Mark, Taylor, Mark J., Ward, Stephen A.
Publicado 2019

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

por Sharma, Raman, Jayoussi, Ghaith Al, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Myhill, Laura J., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., Ford, Louise, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J.
Publicado 2016

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

por Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Myhill, Laura J., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., Ford, Louise, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J.
Publicado 2018

Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis

por McGillan, Paul, Berry, Neil G., Nixon, Gemma L., Leung, Suet C., Webborn, Peter J. H., Wenlock, Mark C., Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H., Cook, Darren A., Johnston, Kelly L., Ford, Louise, Ward, Stephen A., Taylor, Mark J., Hong, W. David, O’Neill, Paul M.
Publicado 2021

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis

por Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., Taylor, Mark J.
Publicado 2017

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

por Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2017

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

por Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2018

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

por Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.
Publicado 2019

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

por Jacobs, Robert T., Lunde, Christopher S., Freund, Yvonne R., Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S., Berry, Pamela W., Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J., Ford, Louise, Johnston, Kelly L., Cook, Darren A. N., Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F., Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J., Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P., McNamara, Case W., Bakowski, Malina A., Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.
Publicado 2019

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

por Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.
Publicado 2019