Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment

por Carlin, Aaron F., Clark, Alex E., Chaillon, Antoine, Garretson, Aaron F., Bray, William, Porrachi, Magali, Santos, AsherLev T., Smith, Davey M.
Publicado 2022

A Human 3D neural assembloid model for SARS-CoV-2 infection

por Wang, Lu, Sievert, David, Gleeson, Joseph, Clark, Alex E., Carlin, Aaron F., Federman, Hannah, Gastfriend, Benjamin D., Shusta, Eric, Palecek, Sean P.
Publicado 2021

Neutralizing Antibody Responses After Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 and BA.2.12.1 Infection Do Not Neutralize BA.4 and BA.5 and Can Be Blunted by Nirmatrelvi...

por Carlin, Aaron F, Clark, Alex E, Garretson, Aaron F, Bray, William, Porrachia, Magali, Santos, AsherLev T, Rana, Tariq M, Chaillon, Antoine, Smith, Davey M
Publicado 2023

A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening...

por Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Publicado 2022

PCIF1-mediated deposition of 5′-cap N(6),2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection

por Wang, Lingling, Wang, Shaobo, Wu, Lujing, Li, Wanyu, Bray, William, Clark, Alex E., Gonzalez, Gwendolyn Michelle, Wang, Yinsheng, Carlin, Aaron F., Rana, Tariq M.
Publicado 2023

Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors

por Huff, Sarah, Kummetha, Indrasena Reddy, Tiwari, Shashi Kant, Huante, Matthew B., Clark, Alex E., Wang, Shaobo, Bray, William, Smith, Davey, Carlin, Aaron F., Endsley, Mark, Rana, Tariq M.
Publicado 2021

Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

por Almanza, Gonzalo, Clark, Alex E., Kouznetsova, Valentina, Olmedillas, Eduardo, Castro, Andrea, Tsigelny, Igor F., Wu, Yan, Gao, George F., Leibel, Sandra L., Bray, William, Ollmann Saphire, Erica, Carlin, Aaron F., Zanetti, Maurizio
Publicado 2022

Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells

por Bernatchez, Jean A., Coste, Michael, Beck, Sungjun, Wells, Grace A., Luna, Lucas A., Clark, Alex E., Zhu, Zhe, Hecht, David, Rich, Jeremy N., Sohl, Christal D., Purse, Byron W., Siqueira-Neto, Jair L.
Publicado 2019

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

por Sen, Arko, Prager, Briana C., Zhong, Cuiqing, Park, Donglim, Zhu, Zhe, Gimple, Ryan C., Wu, Qiulian, Bernatchez, Jean A., Beck, Sungjun, Clark, Alex E., Siqueira-Neto, Jair L., Rich, Jeremy N., McVicker, Graham
Publicado 2022

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

por Li, Ruofan, Mor, Michael, Ma, Bingting, Clark, Alex E., Alter, Joel, Werbner, Michal, Lee, Jamie Casey, Leibel, Sandra L., Carlin, Aaron F., Dessau, Moshe, Gal-Tanamy, Meital, Croker, Ben A., Xiang, Ye, Freund, Natalia T.
Publicado 2022

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity

por Park, Sang Ho, Siddiqi, Haley, Castro, Daniela V., De Angelis, Anna A., Oom, Aaron L., Stoneham, Charlotte A., Lewinski, Mary K., Clark, Alex E., Croker, Ben A., Carlin, Aaron F., Guatelli, John, Opella, Stanley J.
Publicado 2021

Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs

por Schooley, Robert T., Carlin, Aaron F., Beadle, James R., Valiaeva, Nadejda, Zhang, Xing-Quan, Clark, Alex E., McMillan, Rachel E., Leibel, Sandra L., McVicar, Rachael N., Xie, Jialei, Garretson, Aaron F., Smith, Victoria I., Murphy, Joyce, Hostetler, Karl Y.
Publicado 2021

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs

por Schooley, Robert T., Carlin, Aaron F., Beadle, James R., Valiaeva, Nadejda, Zhang, Xing-Quan, Clark, Alex E., McMillan, Rachel E., Leibel, Sandra L., McVicar, Rachael N., Xie, Jialei, Garretson, Aaron F., Smith, Victoria I., Murphy, Joyce, Hostetler, Karl Y.
Publicado 2021

RNA binding protein CPEB1 remodels host and viral RNA landscapes

por Batra, Ranjan, Stark, Thomas J., Clark, Alex E., Belzile, Jean-Philippe, Wheeler, Emily C., Yee, Brian A., Huang, Hui, Gelboin-Burkhart, Chelsea, Huelga, Stephanie C., Aigner, Stefan, Roberts, Brett T., Bos, Tomas J., Sathe, Shashank, Donohue, John Paul, Rigo, Frank, Ares, Manuel, Spector, Deborah H., Yeo, Gene W.
Publicado 2016

In Vitro Diagnostic Assay to Detect SARS-CoV-2-Neutralizing Antibody in Patient Sera Using Engineered ACE-2 Mini-Protein

por Pereira de Jesus, Bruna Andersen, Gomes, Anderson Albino, Clark, Alex E., Rodrigues, Tayse Andrade, Ledgerwood-Lee, Melissa, Van Zant, Westley, Brickner, Howard, Wang, Meiqiao, Blum, David L., Cassera, Maria B., Carlin, Aaron F., Aronoff-Spencer, Eliah S., da Silva, Gustavo Felippe, Magalhães, Maria de Lourdes Borba, Ray, Partha
Publicado 2022

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additi...

por Carlin, Aaron F., Beadle, James R., Clark, Alex E., Gully, Kendra L., Moreira, Fernando R., Baric, Ralph S., Graham, Rachel L., Valiaeva, Nadejda, Leibel, Sandra L., Bray, William, McMillan, Rachel E., Freshman, Jonathan E., Garretson, Aaron F., McVicar, Rachael N., Rana, Tariq, Zhang, Xing-Quan, Murphy, Joyce A., Schooley, Robert T., Hostetler, Karl Y.
Publicado 2023

SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus

por Branche, Emilie, Wang, Ying-Ting, Viramontes, Karla M., Valls Cuevas, Joan M., Xie, Jialei, Ana-Sosa-Batiz, Fernanda, Shafee, Norazizah, Duttke, Sascha H., McMillan, Rachel E., Clark, Alex E., Nguyen, Michael N., Garretson, Aaron F., Crames, Jan J., Spann, Nathan J., Zhu, Zhe, Rich, Jeremy N., Spector, Deborah H., Benner, Christopher, Shresta, Sujan, Carlin, Aaron F.
Publicado 2022

Identification of global inhibitors of cellular glycosylation

por Sørensen, Daniel Madriz, Büll, Christian, Madsen, Thomas D., Lira-Navarrete, Erandi, Clausen, Thomas Mandel, Clark, Alex E., Garretson, Aaron F., Karlsson, Richard, Pijnenborg, Johan F. A., Yin, Xin, Miller, Rebecca L., Chanda, Sumit K., Boltje, Thomas J., Schjoldager, Katrine T., Vakhrushev, Sergey Y., Halim, Adnan, Esko, Jeffrey D., Carlin, Aaron F., Hurtado-Guerrero, Ramon, Weigert, Roberto, Clausen, Henrik, Narimatsu, Yoshiki
Publicado 2023

Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors

por Mor, Michael, Werbner, Michal, Alter, Joel, Safra, Modi, Chomsky, Elad, Hada-Neeman, Smadar, Polonsky, Ksenia, Nowell, Cameron J., Clark, Alex E., Roitburd-Berman, Anna, Shalom, Noam Ben, Navon, Michal, Rafael, Dor, Sharim, Hila, Kiner, Evgeny, Griffis, Eric, Gershoni, Jonathan M., Kobiler, Oren, Leibel, Sandra Lawrynowicz, Zimhony, Oren, Carlin, Aaron F., Yaari, Gur, Dassau, Moshe, Gal-Tanamy, Meital, Hagin, David, Croker, Ben A., Freund, Natalia T.
Publicado 2020

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors

por Mor, Michael, Werbner, Michal, Alter, Joel, Safra, Modi, Chomsky, Elad, Lee, Jamie C., Hada-Neeman, Smadar, Polonsky, Ksenia, Nowell, Cameron J., Clark, Alex E., Roitburd-Berman, Anna, Ben-Shalom, Noam, Navon, Michal, Rafael, Dor, Sharim, Hila, Kiner, Evgeny, Griffis, Eric R., Gershoni, Jonathan M., Kobiler, Oren, Leibel, Sandra Lawrynowicz, Zimhony, Oren, Carlin, Aaron F., Yaari, Gur, Dessau, Moshe, Gal-Tanamy, Meital, Hagin, David, Croker, Ben A., Freund, Natalia T.
Publicado 2021