Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination

por Clark, Alex J., Kaller, Malte S., Galino, Jorge, Willison, Hugh J., Rinaldi, Simon, Bennett, David L. H.
Publicado 2017

Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source

por Weir, Greg A, Middleton, Steven J, Clark, Alex J, Daniel, Tarun, Khovanov, Nikita, McMahon, Stephen B, Bennett, David L
Publicado 2017

Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro

por Wilson, Emma R., Kugathasan, Umaiyal, Abramov, Andrey Y., Clark, Alex J., Bennett, David L.H., Reilly, Mary M., Greensmith, Linda, Kalmar, Bernadett
Publicado 2018

Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury

por Baskozos, Georgios, Dawes, John M., Austin, Jean S., Antunes-Martins, Ana, McDermott, Lucy, Clark, Alex J., Trendafilova, Teodora, Lees, Jon G., McMahon, Stephen B., Mogil, Jeffrey S., Orengo, Christine, Bennett, David L.
Publicado 2018

Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth

por Baskozos, Georgios, Sandy-Hindmarch, Oliver, Clark, Alex J, Windsor, Katherine, Karlsson, Pall, Weir, Greg A, McDermott, Lucy A, Burchall, Joanna, Wiberg, Akira, Furniss, Dominic, Bennett, David L H, Schmid, Annina B
Publicado 2020

Defining the Functional Role of Na(V)1.7 in Human Nociception

por McDermott, Lucy A., Weir, Greg A., Themistocleous, Andreas C., Segerdahl, Andrew R., Blesneac, Iulia, Baskozos, Georgios, Clark, Alex J., Millar, Val, Peck, Liam J., Ebner, Daniel, Tracey, Irene, Serra, Jordi, Bennett, David L.
Publicado 2019

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons

por Perez-Sanchez, Jimena, Middleton, Steven J., Pattison, Luke A., Hilton, Helen, Awadelkareem, Mosab Ali, Zuberi, Sana R., Renke, Maria B., Hu, Huimin, Yang, Xun, Clark, Alex J., Smith, Ewan St. John, Bennett, David L.
Publicado 2023

An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions

por Clark, Alex J., Kugathasan, Umaiyal, Baskozos, Georgios, Priestman, David A., Fugger, Nadine, Lone, Museer A., Othman, Alaa, Chu, Ka Hing, Blesneac, Iulia, Wilson, Emma R., Laurà, Matilde, Kalmar, Bernadett, Greensmith, Linda, Hornemann, Thorsten, Platt, Frances M., Reilly, Mary M., Bennett, David L.
Publicado 2021

Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability

por Dawes, John M., Weir, Greg A., Middleton, Steven J., Patel, Ryan, Chisholm, Kim I., Pettingill, Philippa, Peck, Liam J., Sheridan, Joseph, Shakir, Akila, Jacobson, Leslie, Gutierrez-Mecinas, Maria, Galino, Jorge, Walcher, Jan, Kühnemund, Johannes, Kuehn, Hannah, Sanna, Maria D., Lang, Bethan, Clark, Alex J., Themistocleous, Andreas C., Iwagaki, Noboru, West, Steven J., Werynska, Karolina, Carroll, Liam, Trendafilova, Teodora, Menassa, David A., Giannoccaro, Maria Pia, Coutinho, Ester, Cervellini, Ilaria, Tewari, Damini, Buckley, Camilla, Leite, M. Isabel, Wildner, Hendrik, Zeilhofer, Hanns Ulrich, Peles, Elior, Todd, Andrew J., McMahon, Stephen B., Dickenson, Anthony H., Lewin, Gary R., Vincent, Angela, Bennett, David L.
Publicado 2018