Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

por Tripathi, Kaushlendra, Mani, Chinnadurai, Clark, David W, Palle, Komaraiah
Publicado 2016

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

por Clark, David W., Tripathi, Kaushlendra, Dorsman, Josephine C., Palle, Komaraiah
Publicado 2015

The Multifunctional Protein PACS-1 is Required for HDAC2 and HDAC3 Dependent Chromatin Maturation and Genomic Stability

por Mani, Chinnadurai, Tripathi, Kaushlendra, Luan, Shan, Clark, David W., Andrews, Joel F., Vindigni, Alessandro, Thomas, Gary, Palle, Komaraiah
Publicado 2020

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation

por Samant, Rajeev S, Clark, David W, Fillmore, Rebecca A, Cicek, Muzaffer, Metge, Brandon J, Chandramouli, Kondethimmana H, Chambers, Ann F, Casey, Graham, Welch, Danny R, Shevde, Lalita A
Publicado 2007

Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study

por Ceballos, Francisco C., Hazelhurst, Scott, Clark, David W., Agongo, Godfred, Asiki, Gershim, Boua, Palwende R., Xavier Gómez-Olivé, F., Mashinya, Felistas, Norris, Shane, Wilson, James F., Ramsay, Michèle
Publicado 2020

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

por Somasagara, Ranganatha R., Spencer, Sebastian M., Tripathi, Kaushlendra, Clark, David W., Mani, Chinnadurai, da Silva, Luciana Madeira, Scalici, Jennifer, Kothayer, Hend, Westwell, Andrew D., Rocconi, Rodney P., Palle, Komaraiah
Publicado 2017

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

por Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K
Publicado 2019

Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

por Bretherick, Andrew D., Canela-Xandri, Oriol, Joshi, Peter K., Clark, David W., Rawlik, Konrad, Boutin, Thibaud S., Zeng, Yanni, Amador, Carmen, Navarro, Pau, Rudan, Igor, Wright, Alan F., Campbell, Harry, Vitart, Veronique, Hayward, Caroline, Wilson, James F., Tenesa, Albert, Ponting, Chris P., Baillie, J. Kenneth, Haley, Chris
Publicado 2020

The genetic landscape of Scotland and the Isles

por Gilbert, Edmund, O’Reilly, Seamus, Merrigan, Michael, McGettigan, Darren, Vitart, Veronique, Joshi, Peter K., Clark, David W., Campbell, Harry, Hayward, Caroline, Ring, Susan M., Golding, Jean, Goodfellow, Stephanie, Navarro, Pau, Kerr, Shona M., Amador, Carmen, Campbell, Archie, Haley, Chris S., Porteous, David J., Cavalleri, Gianpiero L., Wilson, James F.
Publicado 2019

Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

por Zeng, Yanni, Amador, Carmen, Xia, Charley, Marioni, Riccardo, Sproul, Duncan, Walker, Rosie M., Morris, Stewart W., Bretherick, Andrew, Canela-Xandri, Oriol, Boutin, Thibaud S., Clark, David W., Campbell, Archie, Rawlik, Konrad, Hayward, Caroline, Nagy, Reka, Tenesa, Albert, Porteous, David J., Wilson, James F., Deary, Ian J., Evans, Kathryn L., McIntosh, Andrew M., Navarro, Pau, Haley, Chris S.
Publicado 2019

Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

por Zeng, Yanni, Amador, Carmen, Xia, Charley, Marioni, Riccardo, Sproul, Duncan, Walker, Rosie M., Morris, Stewart W., Bretherick, Andrew, Canela-Xandri, Oriol, Boutin, Thibaud S., Clark, David W., Campbell, Archie, Rawlik, Konrad, Hayward, Caroline, Nagy, Reka, Tenesa, Albert, Porteous, David J., Wilson, James F., Deary, Ian J., Evans, Kathryn L., McIntosh, Andrew M., Navarro, Pau, Haley, Chris S.
Publicado 2019

Genome‐Wide Association Study of NAFLD Using Electronic Health Records

por Fairfield, Cameron J., Drake, Thomas M., Pius, Riinu, Bretherick, Andrew D., Campbell, Archie, Clark, David W., Fallowfield, Jonathan A., Hayward, Caroline, Henderson, Neil C., Joshi, Peter K., Mills, Nicholas L., Porteous, David J., Ramachandran, Prakash, Semple, Robert K., Shaw, Catherine A., Sudlow, Cathie L.M., Timmers, Paul R.H.J., Wilson, James F., Wigmore, Stephen J., Harrison, Ewen M., Spiliopoulou, Athina
Publicado 2021

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of card...

por Crawford, Andrew A., Bankier, Sean, Altmaier, Elisabeth, Barnes, Catriona L. K., Clark, David W., Ermel, Raili, Friedrich, Nele, van der Harst, Pim, Joshi, Peter K., Karhunen, Ville, Lahti, Jari, Mahajan, Anubha, Mangino, Massimo, Nethander, Maria, Neumann, Alexander, Pietzner, Maik, Sukhavasi, Katyayani, Wang, Carol A., Bakker, Stephan J. L., Bjorkegren, Johan L. M., Campbell, Harry, Eriksson, Johan, Gieger, Christian, Hayward, Caroline, Jarvelin, Marjo-Riitta, McLachlan, Stela, Morris, Andrew P., Ohlsson, Claes, Pennell, Craig E., Price, Jackie, Rudan, Igor, Ruusalepp, Arno, Spector, Tim, Tiemeier, Henning, Völzke, Henry, Wilson, James F., Michoel, Tom, Timpson, Nicolas J., Smith, George Davey, Walker, Brian R.
Publicado 2021

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

por Joshi, Peter K., Pirastu, Nicola, Kentistou, Katherine A., Fischer, Krista, Hofer, Edith, Schraut, Katharina E., Clark, David W., Nutile, Teresa, Barnes, Catriona L. K., Timmers, Paul R. H. J., Shen, Xia, Gandin, Ilaria, McDaid, Aaron F., Hansen, Thomas Folkmann, Gordon, Scott D., Giulianini, Franco, Boutin, Thibaud S., Abdellaoui, Abdel, Zhao, Wei, Medina-Gomez, Carolina, Bartz, Traci M., Trompet, Stella, Lange, Leslie A., Raffield, Laura, van der Spek, Ashley, Galesloot, Tessel E., Proitsi, Petroula, Yanek, Lisa R., Bielak, Lawrence F., Payton, Antony, Murgia, Federico, Concas, Maria Pina, Biino, Ginevra, Tajuddin, Salman M., Seppälä, Ilkka, Amin, Najaf, Boerwinkle, Eric, Børglum, Anders D., Campbell, Archie, Demerath, Ellen W., Demuth, Ilja, Faul, Jessica D., Ford, Ian, Gialluisi, Alessandro, Gögele, Martin, Graff, MariaElisa, Hingorani, Aroon, Hottenga, Jouke-Jan, Hougaard, David M., Hurme, Mikko A., Ikram, M. Arfan, Jylhä, Marja, Kuh, Diana, Ligthart, Lannie, Lill, Christina M., Lindenberger, Ulman, Lumley, Thomas, Mägi, Reedik, Marques-Vidal, Pedro, Medland, Sarah E., Milani, Lili, Nagy, Reka, Ollier, William E. R., Peyser, Patricia A., Pramstaller, Peter P., Ridker, Paul M., Rivadeneira, Fernando, Ruggiero, Daniela, Saba, Yasaman, Schmidt, Reinhold, Schmidt, Helena, Slagboom, P. Eline, Smith, Blair H., Smith, Jennifer A., Sotoodehnia, Nona, Steinhagen-Thiessen, Elisabeth, van Rooij, Frank J. A., Verbeek, André L., Vermeulen, Sita H., Vollenweider, Peter, Wang, Yunpeng, Werge, Thomas, Whitfield, John B., Zonderman, Alan B., Lehtimäki, Terho, Evans, Michele K., Pirastu, Mario, Fuchsberger, Christian, Bertram, Lars, Pendleton, Neil, Kardia, Sharon L. R., Ciullo, Marina, Becker, Diane M., Wong, Andrew, Psaty, Bruce M., van Duijn, Cornelia M., Wilson, James G., Jukema, J. Wouter, Kiemeney, Lambertus, Uitterlinden, André G., Franceschini, Nora, North, Kari E., Weir, David R., Metspalu, Andres, Boomsma, Dorret I., Hayward, Caroline, Chasman, Daniel, Martin, Nicholas G., Sattar, Naveed, Campbell, Harry, Esko, Tōnu, Kutalik, Zoltán, Wilson, James F.
Publicado 2017

Associations of autozygosity with a broad range of human phenotypes

por Clark, David W, Okada, Yukinori, Moore, Kristjan H S, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona L K, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, de Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, van der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, van der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, de Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander S F, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, de Kleijn, Dominique P V, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian’an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, de Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, van Rooij, Frank J A, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan J L, Becker, Diane M, Lehne, Benjamin, Bennett, David A, van den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan F A, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, van der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent W V, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kumari, Meena, Laakso, Markku, van der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O’connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca J. C., Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik K. E., Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth J. F., Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John R. B., Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, Wilson, James F
Publicado 2019