Evolutionary Signatures amongst Disease Genes Permit Novel Methods for Gene Prioritization and Construction of Informative Gene-Based Networks

por Priedigkeit, Nolan, Wolfe, Nicholas, Clark, Nathan L.
Publicado 2015

Pan-mammalian analysis of molecular constraints underlying extended lifespan

por Kowalczyk, Amanda, Partha, Raghavendran, Clark, Nathan L, Chikina, Maria
Publicado 2020

Experimental exchange of paralogous domains in the MLH family provides evidence of sub-functionalization after gene duplication

por Furman, Christopher M, Elbashir, Ryan, Pannafino, Gianno, Clark, Nathan L, Alani, Eric
Publicado 2021

Highly Dynamic Gene Family Evolution Suggests Changing Roles for PON Genes Within Metazoa

por Lucas, Sarah A M, Graham, Allie M, Presnell, Jason S, Clark, Nathan L
Publicado 2023

Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

por Hancks, Dustin C., Hartley, Melissa K., Hagan, Celia, Clark, Nathan L., Elde, Nels C.
Publicado 2015

Activation by cleavage of the epithelial Na(+) channel α and γ subunits independently coevolved with the vertebrate terrestrial migration

por Wang, Xue-Ping, Balchak, Deidra M, Gentilcore, Clayton, Clark, Nathan L, Kashlan, Ossama B
Publicado 2022

Digestive Organ in the Female Reproductive Tract Borrows Genes from Multiple Organ Systems to Adopt Critical Functions

por Meslin, Camille, Plakke, Melissa S., Deutsch, Aaron B., Small, Brandon S., Morehouse, Nathan I., Clark, Nathan L.
Publicado 2015

Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses

por Findlay, Geoffrey D., Sitnik, Jessica L., Wang, Wenke, Aquadro, Charles F., Clark, Nathan L., Wolfner, Mariana F.
Publicado 2014

Gadusol is a maternally provided sunscreen that protects fish embryos from DNA damage

por Rice, Marlen C., Little, Jordan H., Forrister, Dale L., Machado, Julane, Clark, Nathan L., Gagnon, James A.
Publicado 2023

Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

por Partha, Raghavendran, Chauhan, Bharesh K, Ferreira, Zelia, Robinson, Joseph D, Lathrop, Kira, Nischal, Ken K, Chikina, Maria, Clark, Nathan L
Publicado 2017

Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage

por Clancy, Cornelius J., Meslin, Camille, Badrane, Hassan, Cheng, Shaoji, Losada, Liliana C., Nierman, William C., Vergidis, Pascalis, Clark, Nathan L., Nguyen, M. Hong
Publicado 2016

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila

por Raza, Qanber, Choi, Jae Young, Li, Yang, O’Dowd, Roisin M., Watkins, Simon C., Chikina, Maria, Hong, Yang, Clark, Nathan L., Kwiatkowski, Adam V.
Publicado 2019

The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae

por Ziegler, Anna B., Augustin, Hrvoje, Clark, Nathan L., Berthelot-Grosjean, Martine, Simonnet, Mégane M., Steinert, Joern R., Geillon, Flore, Manière, Gérard, Featherstone, David E., Grosjean, Yael
Publicado 2016

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

por Talsness, Dana M, Owings, Katie G, Coelho, Emily, Mercenne, Gaelle, Pleinis, John M, Partha, Raghavendran, Hope, Kevin A, Zuberi, Aamir R, Clark, Nathan L, Lutz, Cathleen M, Rodan, Aylin R, Chow, Clement Y
Publicado 2020

The molecular genetic basis of herbivory between butterflies and their host-plants

por Nallu, Sumitha, Don, Kristine, Sahagun, Carlos, Zhang, Wei, Bergelson, Joy, Kronforst*, Marcus R., Hill, Jason A., Wheat, Christopher W., Meslin, Camille, Clark, Nathan L., Snell-Rood, Emilie, Morehouse, Nathan I., Zhang, W., Meslin, C.
Publicado 2018

Reduction of Paraoxonase Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization

por Graham, Allie M, Jamison, Jerrica M, Bustos, Marisol, Cournoyer, Charlotte, Michaels, Alexa, Presnell, Jason S, Richter, Rebecca, Crocker, Daniel E, Fustukjian, Ari, Hunter, Margaret E, Rea, Lorrie D, Marsillach, Judit, Furlong, Clement E, Meyer, Wynn K, Clark, Nathan L
Publicado 2023

MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

por Huang, Jen-Wei, Acharya, Ananya, Taglialatela, Angelo, Nambiar, Tarun S., Cuella-Martin, Raquel, Leuzzi, Giuseppe, Hayward, Samuel B., Joseph, Sarah A., Brunette, Gregory J., Anand, Roopesh, Soni, Rajesh K., Clark, Nathan L., Bernstein, Kara A., Cejka, Petr, Ciccia, Alberto
Publicado 2020

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

por Pereira, Catalina, Arroyo-Martinez, Gerardo A, Guo, Matthew Z, Downey, Michael S, Kelly, Emma R, Grive, Kathryn J, Mahadevaiah, Shantha K, Sims, Jennie R, Faca, Vitor M, Tsai, Charlton, Schiltz, Carl J, Wit, Niek, Jacobs, Heinz, Clark, Nathan L, Freire, Raimundo, Turner, James, Lyndaker, Amy M, Brieno-Enriquez, Miguel A, Cohen, Paula E, Smolka, Marcus B, Weiss, Robert S
Publicado 2022