Adapting the chemical unfolding assay for high-throughput protein screening using experimental and spectroscopic corrections

por Floyd, J. Alaina, Siska, Christine, Clark, Rutilio H., Kerwin, Bruce A., Shaver, Jeremy M.
Publicado 2018

Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs

por Clark, Rutilio H, Latypov, Ramil F, De Imus, Cyr, Carter, Jane, Wilson, Zien, Manchulenko, Kathy, Brown, Michael E, Ketchem, Randal R
Publicado 2014

Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity

por Kerwin, Bruce A., Bennett, Chelsey, Brodsky, Yan, Clark, Rutilio, Floyd, J. Alaina, Gillespie, Alison, Mayer, Bryan T., McClure, Megan, Siska, Christine, Seaman, Michael S., Seaton, Kelly E., Shaver, Jeremy, Tomaras, Georgia D., Yates, Nicole L., Ketchem, Randal R.
Publicado 2020