Considerations for defining +80 Da mass shifts in mass spectrometry-based proteomics: phosphorylation and beyond

por Daly, Leonard A., Clarke, Christopher J., Po, Allen, Oswald, Sally O., Eyers, Claire E.
Publicado 2023

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

por Liu, Mengling, Clarke, Christopher J., Salama, Mohamed F., Choi, Yeon Ja, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2017

Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor

por Liu, Mengling, Idkowiak-Baldys, Jolanta, Roddy, Patrick L., Baldys, Aleksander, Raymond, John, Clarke, Christopher J., Hannun, Yusuf A.
Publicado 2013

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization

por Khavandgar, Zohreh, Poirier, Christophe, Clarke, Christopher J., Li, Jingjing, Wang, Nicholas, McKee, Marc D., Hannun, Yusuf A., Murshed, Monzur
Publicado 2011

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

por Hernández-Corbacho, María José, Jenkins, Russell W., Clarke, Christopher J., Hannun, Yusuf A., Obeid, Lina M., Snider, Ashley J., Siskind, Leah J.
Publicado 2011

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides

por Trayssac, Magali, Clarke, Christopher J., Stith, Jeffrey L., Snider, Justin M., Newen, Naomi, Gault, Christopher R., Hannun, Yusuf A., Obeid, Lina M.
Publicado 2021

PKCα is required for Akt-mTORC1 activation in Non-Small Cell Lung Carcinoma (NSCLC) with EGFR mutation

por Salama, Mohamed F., Liu, Mengling, Clarke, Christopher J., Espaillat, Mel Pilar, Haley, John, Jin, Ting, Wang, Daifeng, Obeid, Lina M., Hannun, Yusuf A.
Publicado 2019

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

por Byrne, Dominic P., Clarke, Christopher J., Brownridge, Philip J., Kalyuzhnyy, Anton, Perkins, Simon, Campbell, Amy, Mason, David, Jones, Andrew R., Eyers, Patrick A., Eyers, Claire E.
Publicado 2020

Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases

por Mohammed, Samia, Shamseddine, Achraf A., Newcomb, Benjamin, Chavez, Ronald S., Panzner, Tyler D., Lee, Allen H., Canals, Daniel, Okeoma, Chioma M., Clarke, Christopher J., Hannun, Yusuf A.
Publicado 2021

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation

por Hardman, Gemma, Perkins, Simon, Brownridge, Philip J, Clarke, Christopher J, Byrne, Dominic P, Campbell, Amy E, Kalyuzhnyy, Anton, Myall, Ashleigh, Eyers, Patrick A, Jones, Andrew R, Eyers, Claire E
Publicado 2019

Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

por Niekamp, Patrick, Scharte, Felix, Sokoya, Tolulope, Vittadello, Laura, Kim, Yeongho, Deng, Yongqiang, Südhoff, Elisabeth, Hilderink, Angelika, Imlau, Mirco, Clarke, Christopher J., Hensel, Michael, Burd, Christopher G., Holthuis, Joost C. M.
Publicado 2022

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

por Gough, Daniel J., Messina, Nicole L., Hii, Linda, Gould, Jodee A., Sabapathy, Kanaga, Robertson, Ashley P. S., Trapani, Joseph A., Levy, David E., Hertzog, Paul J., Clarke, Christopher J. P., Johnstone, Ricky W.
Publicado 2010