Senescence utilises inflammatory caspases to drive SASP

por Wiggins, Kimberley A., Clarke, Murray CH.
Publicado 2019

Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease

por Pyrillou, Katerina, Burzynski, Laura C., Clarke, Murray C. H.
Publicado 2020

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype

por Gardner, Sarah E., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C.H.
Publicado 2015

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION

por Burzynski, Laura C., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C. H.
Publicado 2015

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death

por Clarke, Murray C.H., Savill, John, Jones, David B., Noble, Brendon S., Brown, Simon B.
Publicado 2003

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

por Zheng, Yue, Humphry, Melanie, Maguire, Janet J., Bennett, Martin R., Clarke, Murray C.H.
Publicado 2013

Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells

por Aravani, Dimitra, Foote, Kirsty, Figg, Nichola, Finigan, Alison, Uryga, Anna, Clarke, Murray, Bennett, Martin
Publicado 2020

The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro

por Maguire, Janet J., Jones, Katie L., Kuc, Rhoda E., Clarke, Murray C.H., Bennett, Martin R., Davenport, Anthony P.
Publicado 2014

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production

por Burzynski, Laura C, Morales-Maldonado, Alejandra, Rodgers, Amanda, Kitt, Lauren A, Humphry, Melanie, Figg, Nichola, Bennett, Martin R, Clarke, Murray C H
Publicado 2023

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

por Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Publicado 2019

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

por Burzynski, Laura C., Humphry, Melanie, Pyrillou, Katerina, Wiggins, Kimberley A., Chan, Julie N.E., Figg, Nichola, Kitt, Lauren L., Summers, Charlotte, Tatham, Kate C., Martin, Paul B., Bennett, Martin R., Clarke, Murray C.H.
Publicado 2019

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

por Cassidy, Liam D., Young, Andrew R. J., Young, Christopher N. J., Soilleux, Elizabeth J., Fielder, Edward, Weigand, Bettina M., Lagnado, Anthony, Brais, Rebecca, Ktistakis, Nicholas T., Wiggins, Kimberley A., Pyrillou, Katerina, Clarke, Murray C. H., Jurk, Diana, Passos, Joao F., Narita, Masashi
Publicado 2020

PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

por Baldrighi, Marta, Doreth, Christian, Li, Yang, Zhao, Xiaohui, Warner, Emily, Chenoweth, Hannah, Kishore, Kamal, Umrania, Yagnesh, Minde, David-Paul, Thome, Sarah, Yu, Xian, Lu, Yuning, Knapton, Alice, Harrison, James, Clarke, Murray, Latz, Eicke, de Cárcer, Guillermo, Malumbres, Marcos, Ryffel, Bernhard, Bryant, Clare, Liu, Jinping, Lilley, Kathryn S., Mallat, Ziad, Li, Xuan
Publicado 2023