SASC: A simple approach to synthetic cohorts for generating longitudinal observational patient cohorts from COVID-19 clinical data

por Khorchani, Takoua, Gadiya, Yojana, Witt, Gesa, Lanzillotta, Delia, Claussen, Carsten, Zaliani, Andrea
Publicado 2022

Intravenous Bone Marrow Mononuclear Cells Transplantation in Aged Mice Increases Transcription of Glucose Transporter 1 and Na(+)/K(+)-ATPase at Hippocampus Followed by Restored Ne...

por Takeuchi, Yukiko, Okinaka, Yuka, Ogawa, Yuko, Kikuchi-Taura, Akie, Kataoka, Yosky, Gul, Sheraz, Claussen, Carsten, Boltze, Johannes, Taguchi, Akihiko
Publicado 2020

Increased RNA Transcription of Energy Source Transporters in Circulating White Blood Cells of Aged Mice

por Takeuchi, Yukiko, Saino, Orie, Okinaka, Yuka, Ogawa, Yuko, Akamatsu, Rie, Kikuchi-Taura, Akie, Kataoka, Yosky, Maeda, Mitsuyo, Gul, Sheraz, Claussen, Carsten, Boltze, Johannes, Taguchi, Akihiko
Publicado 2022

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

por Ellinger, Bernhard, Bojkova, Denisa, Zaliani, Andrea, Cinatl, Jindrich, Claussen, Carsten, Westhaus, Sandra, Keminer, Oliver, Reinshagen, Jeanette, Kuzikov, Maria, Wolf, Markus, Geisslinger, Gerd, Gribbon, Philip, Ciesek, Sandra
Publicado 2021

A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism

por Lage-Rupprecht, Vanessa, Schultz, Bruce, Dick, Justus, Namysl, Marcin, Zaliani, Andrea, Gebel, Stephan, Pless, Ole, Reinshagen, Jeanette, Ellinger, Bernhard, Ebeling, Christian, Esser, Alexander, Jacobs, Marc, Claussen, Carsten, Hofmann-Apitius, Martin
Publicado 2022

An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds

por Witt, Gesa, Keminer, Oliver, Leu, Jennifer, Tandon, Rashmi, Meiser, Ina, Willing, Anne, Winschel, Ingo, Abt, Jana-Christin, Brändl, Björn, Sébastien, Isabelle, Friese, Manuel A., Müller, Franz-Josef, Neubauer, Julia C., Claussen, Carsten, Zimmermann, Heiko, Gribbon, Philip, Pless, Ole
Publicado 2020

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

por Zaliani, Andrea, Vangeel, Laura, Reinshagen, Jeanette, Iaconis, Daniela, Kuzikov, Maria, Keminer, Oliver, Wolf, Markus, Ellinger, Bernhard, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Manelfi, Candida, Herzog, Katja, Jochmans, Dirk, De Jonghe, Steven, Chiu, Winston, Francken, Thibault, Schepers, Joost, Collard, Caroline, Abbasi, Kayvan, Claussen, Carsten, Summa, Vincenzo, Beccari, Andrea R., Neyts, Johan, Gribbon, Philip, Leyssen, Pieter
Publicado 2022

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

por Kuzikov, Maria, Costanzi, Elisa, Reinshagen, Jeanette, Esposito, Francesca, Vangeel, Laura, Wolf, Markus, Ellinger, Bernhard, Claussen, Carsten, Geisslinger, Gerd, Corona, Angela, Iaconis, Daniela, Talarico, Carmine, Manelfi, Candida, Cannalire, Rolando, Rossetti, Giulia, Gossen, Jonas, Albani, Simone, Musiani, Francesco, Herzog, Katja, Ye, Yang, Giabbai, Barbara, Demitri, Nicola, Jochmans, Dirk, Jonghe, Steven De, Rymenants, Jasper, Summa, Vincenzo, Tramontano, Enzo, Beccari, Andrea R., Leyssen, Pieter, Storici, Paola, Neyts, Johan, Gribbon, Philip, Zaliani, Andrea
Publicado 2021

A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization

por Schultz, Bruce, Zaliani, Andrea, Ebeling, Christian, Reinshagen, Jeanette, Bojkova, Denisa, Lage-Rupprecht, Vanessa, Karki, Reagon, Lukassen, Sören, Gadiya, Yojana, Ravindra, Neal G., Das, Sayoni, Baksi, Shounak, Domingo-Fernández, Daniel, Lentzen, Manuel, Strivens, Mark, Raschka, Tamara, Cinatl, Jindrich, DeLong, Lauren Nicole, Gribbon, Phil, Geisslinger, Gerd, Ciesek, Sandra, van Dijk, David, Gardner, Steve, Kodamullil, Alpha Tom, Fröhlich, Holger, Peitsch, Manuel, Jacobs, Marc, Hoeng, Julia, Eils, Roland, Claussen, Carsten, Hofmann-Apitius, Martin
Publicado 2021

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

por Krasemann, Susanne, Haferkamp, Undine, Pfefferle, Susanne, Woo, Marcel S., Heinrich, Fabian, Schweizer, Michaela, Appelt-Menzel, Antje, Cubukova, Alevtina, Barenberg, Janica, Leu, Jennifer, Hartmann, Kristin, Thies, Edda, Littau, Jessica Lisa, Sepulveda-Falla, Diego, Zhang, Liang, Ton, Kathy, Liang, Yan, Matschke, Jakob, Ricklefs, Franz, Sauvigny, Thomas, Sperhake, Jan, Fitzek, Antonia, Gerhartl, Anna, Brachner, Andreas, Geiger, Nina, König, Eva-Maria, Bodem, Jochen, Franzenburg, Sören, Franke, Andre, Moese, Stefan, Müller, Franz-Josef, Geisslinger, Gerd, Claussen, Carsten, Kannt, Aimo, Zaliani, Andrea, Gribbon, Philip, Ondruschka, Benjamin, Neuhaus, Winfried, Friese, Manuel A., Glatzel, Markus, Pless, Ole
Publicado 2022