Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

por Dhoonmoon, Ashna, Schleicher, Emily M, Clements, Kristen E, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado 2020

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

por Clements, Kristen E, Thakar, Tanay, Nicolae, Claudia M, Liang, Xinwen, Wang, Hong-Gang, Moldovan, George-Lucian
Publicado 2018

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

por Thakar, Tanay, Leung, Wendy, Nicolae, Claudia M., Clements, Kristen E., Shen, Binghui, Bielinsky, Anja-Katrin, Moldovan, George-Lucian
Publicado 2020

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado 2020

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

por Clements, Kristen E., Schleicher, Emily M., Thakar, Tanay, Hale, Anastasia, Dhoonmoon, Ashna, Tolman, Nathanial J., Sharma, Anchal, Liang, Xinwen, Imamura Kawasawa, Yuka, Nicolae, Claudia M., Wang, Hong-Gang, De, Subhajyoti, Moldovan, George-Lucian
Publicado 2020