Predicting changes to I(Na) from missense mutations in human SCN5A

por Clerx, Michael, Heijman, Jordi, Collins, Pieter, Volders, Paul G. A.
Publicado 2018

Four Ways to Fit an Ion Channel Model

por Clerx, Michael, Beattie, Kylie A., Gavaghan, David J., Mirams, Gary R.
Publicado 2019

Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia

por Clerx, Michael, Mirams, Gary R., Rogers, Albert J., Narayan, Sanjiv M., Giles, Wayne R.
Publicado 2021

Calibration of ionic and cellular cardiac electrophysiology models

por Whittaker, Dominic G., Clerx, Michael, Lei, Chon Lok, Christini, David J., Mirams, Gary R.
Publicado 2020

Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

por Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken
Publicado 2019

Reproducible model development in the cardiac electrophysiology Web Lab

por Daly, Aidan C., Clerx, Michael, Beattie, Kylie A., Cooper, Jonathan, Gavaghan, David J., Mirams, Gary R.
Publicado 2018

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment

por Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J., Lei, Chon Lok
Publicado 2023

Models of the cardiac L‐type calcium current: A quantitative review

por Agrawal, Aditi, Wang, Ken, Polonchuk, Liudmila, Cooper, Jonathan, Hendrix, Maurice, Gavaghan, David J., Mirams, Gary R., Clerx, Michael
Publicado 2022

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

por Lei, Chon Lok, Clerx, Michael, Whittaker, Dominic G., Gavaghan, David J., de Boer, Teun P., Mirams, Gary R.
Publicado 2020

cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians

por Hendrix, Maurice, Clerx, Michael, Tamuri, Asif U, Keating, Sarah M, Johnstone, Ross H, Cooper, Jonathan, Mirams, Gary R
Publicado 2022

Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems

por Lambert, Ben, Lei, Chon Lok, Robinson, Martin, Clerx, Michael, Creswell, Richard, Ghosh, Sanmitra, Tavener, Simon, Gavaghan, David J.
Publicado 2023

CellML 2.0.1

por Clerx, Michael, Cooling, Michael T., Cooper, Jonathan, Garny, Alan, Moyle, Keri, Nickerson, David P., Nielsen, Poul M. F., Sorby, Hugh
Publicado 2023

Physiology-based regularization of the electrocardiographic inverse problem

por Cluitmans, Matthijs J. M., Clerx, Michael, Vandersickel, Nele, Peeters, Ralf L. M., Volders, Paul G. A., Westra, Ronald L.
Publicado 2016

CellML 2.0

por Clerx, Michael, Cooling, Michael T., Cooper, Jonathan, Garny, Alan, Moyle, Keri, Nickerson, David P., Nielsen, Poul M. F., Sorby, Hugh
Publicado 2020

Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings

por Clark, Alexander P, Clerx, Michael, Wei, Siyu, Lei, Chon Lok, de Boer, Teun P, Mirams, Gary R, Christini, David J, Krogh-Madsen, Trine
Publicado 2023

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

por Lei, Chon Lok, Clerx, Michael, Beattie, Kylie A., Melgari, Dario, Hancox, Jules C., Gavaghan, David J., Polonchuk, Liudmila, Wang, Ken, Mirams, Gary R.
Publicado 2019

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

por Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.
Publicado 2021

A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

por Barral, Yann-Stanislas H. M., Shuttleworth, Joseph G., Clerx, Michael, Whittaker, Dominic G., Wang, Ken, Polonchuk, Liudmila, Gavaghan, David J., Mirams, Gary R.
Publicado 2022

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

por Lei, Chon Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H., Hortigon-Vinagre, Maria P., Zamora, Victor, Allan, Andrew, Smith, Godfrey L., Gavaghan, David J., Mirams, Gary R., Polonchuk, Liudmila
Publicado 2017