Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

por Cline, Gary W.
Publicado 2011

The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans

por Petersen, Kitt Falk, Impellizeri, Anne, Cline, Gary W., Shulman, Gerald I.
Publicado 2019

Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

por Wendel, Angela A., Li, Lei O., Li, Yue, Cline, Gary W., Shulman, Gerald I., Coleman, Rosalind A.
Publicado 2010

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

por Stark, Romana, Pasquel, Francisco, Turcu, Adina, Pongratz, Rebecca L., Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.
Publicado 2009

A role for foregut tyrosine metabolism in glucose tolerance

por Korner, Judith, Cline, Gary W., Slifstein, Mark, Barba, Pasquale, Rayat, Gina R., Febres, Gerardo, Leibel, Rudolph L., Maffei, Antonella, Harris, Paul E.
Publicado 2019

Mechanism for the Anti-Diabetic Effect of Leptin

por Perry, Rachel J., Zhang, Xian-Man, Zhang, Dongyan, Kumashiro, Naoki, Camporez, Joao-Paulo G., Cline, Gary W., Rothman, Douglas L., Shulman, Gerald I.
Publicado 2014

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

por Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Publicado 2017

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

por Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Publicado 2018

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic (13)C magnetic resonance spectroscopy

por Befroy, Douglas E., Perry, Rachel J., Jain, Nimit, Dufour, Sylvie, Cline, Gary W., Trimmer, Jeff, Brosnan, Julia, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Publicado 2013

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

por Perry, Rachel J., Borders, Candace B., Cline, Gary W., Zhang, Xian-Man, Alves, Tiago C., Petersen, Kitt Falk, Rothman, Douglas L., Kibbey, Richard G., Shulman, Gerald I.
Publicado 2016

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

por Luukkonen, Panu K., Dufour, Sylvie, Lyu, Kun, Zhang, Xian-Man, Hakkarainen, Antti, Lehtimäki, Tiina E., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I., Yki-Järvinen, Hannele
Publicado 2020

Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity

por Galuppo, Brittany, Umano, Giuseppina Rosaria, Li, Zhongyao, Van Name, Michelle, Samuels, Stephanie L., Kien, C. Lawrence, Cline, Gary W., Wagner, David A., Barbieri, Emiliano, Tricò, Domenico, Santoro, Nicola
Publicado 2023

Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndrome

por Perry, Rachel J., Peng, Liang, Barry, Natasha A., Cline, Gary W., Zhang, Dongyan, Cardone, Rebecca L., Petersen, Kitt Falk, Kibbey, Richard G., Goodman, Andrew L., Shulman, Gerald I.
Publicado 2016

Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice

por Goedeke, Leigh, Murt, Kelsey N., Di Francesco, Andrea, Camporez, João Paulo, Nasiri, Ali R., Wang, Yongliang, Zhang, Xian‐Man, Cline, Gary W., de Cabo, Rafael, Shulman, Gerald I.
Publicado 2022

Lysophosphatidic Acid Activates Peroxisome Proliferator Activated Receptor-γ in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1

por Stapleton, Cliona M., Mashek, Douglas G., Wang, Shuli, Nagle, Cynthia A., Cline, Gary W., Thuillier, Philippe, Leesnitzer, Lisa M., Li, Lei O., Stimmel, Julie B., Shulman, Gerald I., Coleman, Rosalind A.
Publicado 2011

Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biologica...

por Wijngaard, Robin, Perramón, Meritxell, Parra-Robert, Marina, Hidalgo, Susana, Butrico, Gina, Morales-Ruiz, Manuel, Zeng, Muling, Casals, Eudald, Jiménez, Wladimiro, Fernández-Varo, Guillermo, Shulman, Gerald I., Cline, Gary W., Casals, Gregori
Publicado 2021

Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

por Abulizi, Abudukadier, Vatner, Daniel F., Ye, Zhang, Wang, Yongliang, Camporez, Joao-Paulo, Zhang, Dongyan, Kahn, Mario, Lyu, Kun, Sirwi, Alaa, Cline, Gary W., Hussain, M. Mahmood, Aspichueta, Patricia, Samuel, Varman T., Shulman, Gerald I.
Publicado 2020

MMAB promotes negative feedback control of cholesterol homeostasis

por Goedeke, Leigh, Canfrán-Duque, Alberto, Rotllan, Noemi, Chaube, Balkrishna, Thompson, Bonne M., Lee, Richard G., Cline, Gary W., McDonald, Jeffrey G., Shulman, Gerald I., Lasunción, Miguel A., Suárez, Yajaira, Fernández-Hernando, Carlos
Publicado 2021

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

por LaMoia, Traci E., Butrico, Gina M., Kalpage, Hasini A., Goedeke, Leigh, Hubbard, Brandon T., Vatner, Daniel F., Gaspar, Rafael C., Zhang, Xian-Man, Cline, Gary W., Nakahara, Keita, Woo, Seungwan, Shimada, Atsuhiro, Hüttemann, Maik, Shulman, Gerald I.
Publicado 2022

Hypophosphatemia promotes lower rates of muscle ATP synthesis

por Pesta, Dominik H., Tsirigotis, Dimitrios N., Befroy, Douglas E., Caballero, Daniel, Jurczak, Michael J., Rahimi, Yasmeen, Cline, Gary W., Dufour, Sylvie, Birkenfeld, Andreas L., Rothman, Douglas L., Carpenter, Thomas O., Insogna, Karl, Petersen, Kitt Falk, Bergwitz, Clemens, Shulman, Gerald I.
Publicado 2016