The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care

por Clohessy, John G., Pandolfi, Pier Paolo
Publicado 2018

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

por Lunardi, Andrea, Webster, Kaitlyn A., Papa, Antonella, Padmani, Bhavik, Clohessy, John G., Bronson, Roderick T., Pandolfi, Pier Paolo
Publicado 2014

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs

por Zhang, Yang, Nguyen, Tuan M., Zhang, Xiao-Ou, Wang, Limei, Phan, Tin, Clohessy, John G., Pandolfi, Pier Paolo
Publicado 2021

The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells

por Fagoonee, Sharmila, Bearzi, Claudia, Di Cunto, Ferdinando, Clohessy, John G., Rizzi, Roberto, Reschke, Markus, Tolosano, Emanuela, Provero, Paolo, Pandolfi, Pier Paolo, Silengo, Lorenzo, Altruda, Fiorella
Publicado 2013

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

por Chen, Ming, Wan, Lixin, Zhang, Jiangwen, Zhang, Jinfang, Mendez, Lourdes, Clohessy, John G., Berry, Kelsey, Victor, Joshua, Yin, Qing, Zhu, Yuan, Wei, Wenyi, Pandolfi, Pier Paolo
Publicado 2018

Targeting of microRNA-22 Suppresses Tumor Spread in a Mouse Model of Triple-Negative Breast Cancer

por Panella, Riccardo, Cotton, Cody A., Maymi, Valerie A., Best, Sachem, Berry, Kelsey E., Lee, Samuel, Batalini, Felipe, Vlachos, Ioannis S., Clohessy, John G., Kauppinen, Sakari, Paolo Pandolfi, Pier
Publicado 2023

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer

por Ali, Azhar, Levantini, Elena, Fhu, Chee Wai, Teo, Jun Ting, Clohessy, John G., Goggi, Julian L., Wu, Chan-shuo, Chen, Leilei, Chin, Tan Min, Tenen, Daniel G
Publicado 2019

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

por Lee, Jonathan D., Paulo, Joao A., Posey, Ryan R., Mugoni, Vera, Kong, Nikki R., Cheloni, Giulia, Lee, Yu-Ru, Slack, Frank J., Tenen, Daniel G., Clohessy, John G., Gygi, Steven P., Pandolfi, Pier Paolo
Publicado 2021

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

por Ali, Azhar, Levantini, Elena, Teo, Jun Ting, Goggi, Julian, Clohessy, John G, Wu, Chan Shuo, Chen, Leilei, Yang, Henry, Krishnan, Indira, Kocher, Olivier, Zhang, Junyan, Soo, Ross A, Bhakoo, Kishore, Chin, Tan Min, Tenen, Daniel G
Publicado 2018

Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors

por Chin, Tan-Min, Boopathy, Gandhi T. K., Man, Ellen P.S., Clohessy, John G., Csizmadia, Eva, Quinlan, Margaret P, Putti, Thomas, Wan, Seow-Ching, Xie, Chen, Ali, Azhar, Wai, Fhu Chee, Ong, Yan Shan, Goh, Boon-Cher, Settleman, Jeff, Hong, Wanjin, Levantini, Elena, Tenen, Daniel G.
Publicado 2020

PI3K drives the de novo synthesis of coenzyme A from vitamin B5

por Dibble, Christian C., Barritt, Samuel A., Perry, Grace E., Lien, Evan C., Geck, Renee C., DuBois-Coyne, Sarah E., Bartee, David, Zengeya, Thomas T., Cohen, Emily B., Yuan, Min, Hopkins, Benjamin D., Meier, Jordan L., Clohessy, John G., Asara, John M., Cantley, Lewis C., Toker, Alex
Publicado 2022

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

por Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T., Salmena, Leonardo, Clohessy, John G., Webster, Kaitlyn A., Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C., Lis, Rosina, Patnaik, Akash, Cantley, Lewis C., Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L., Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo
Publicado 2013

The Tug1 lncRNA locus is essential for male fertility

por Lewandowski, Jordan P., Dumbović, Gabrijela, Watson, Audrey R., Hwang, Taeyoung, Jacobs-Palmer, Emily, Chang, Nydia, Much, Christian, Turner, Kyle M., Kirby, Christopher, Rubinstein, Nimrod D., Groff, Abigail F., Liapis, Steve C., Gerhardinger, Chiara, Bester, Assaf, Pandolfi, Pier Paolo, Clohessy, John G., Hoekstra, Hopi E., Sauvageau, Martin, Rinn, John L.
Publicado 2020

Reciprocal inhibition of PIN1 and APC/C(CDH1) controls timely G1/S transition and creates therapeutic vulnerability

por Ke, Shizhong, Dang, Fabin, Wang, Lin, Chen, Jia-Yun, Naik, Mandar T., Thavamani, Abhishek, Liu, Yansheng, Li, Wenxue, Kim, Nami, Naik, Nandita M., Sui, Huaxiu, Tang, Wei, Qiu, Chenxi, Koikawa, Kazuhiro, Batalini, Felipe, Wang, Xiaodong, Clohessy, John G., Heng, Yujing Jan, Lahav, Galit, Gray, Nathanael S., Zho, Xiao Zhen, Wei, Wenyi, Wulf, Gerburg M., Lu, Kun Ping
Publicado 2023

PDX-derived organoids model in vivo drug response and secrete biomarkers

por Huang, Ling, Bockorny, Bruno, Paul, Indranil, Akshinthala, Dipikaa, Frappart, Pierre-Oliver, Gandarilla, Omar, Bose, Arindam, Sanchez-Gonzalez, Veronica, Rouse, Emily E., Lehoux, Sylvain D., Pandell, Nicole, Lim, Christine M., Clohessy, John G., Grossman, Joseph, Gonzalez, Raul, Del Pino, Sofia Perea, Daaboul, George, Sawhney, Mandeep S., Freedman, Steven D., Kleger, Alexander, Cummings, Richard D., Emili, Andrew, Muthuswamy, Lakshmi B., Hidalgo, Manuel, Muthuswamy, Senthil K.
Publicado 2020

Germline NPM1 mutations lead to altered rRNA 2’-O-methylation and cause dyskeratosis congenita

por Nachmani, Daphna, Bothmer, Anne H., Grisendi, Silvia, Mele, Aldo, Bothmer, Dietmar, Lee, Jonathan D., Monteleone, Emanuele, Cheng, Ke, Zhang, Yang, Bester, Assaf C., Guzzetti, Alison, Mitchell, Caitlin A., Mendez, Lourdes M., Pozdnyakova, Olga, Sportoletti, Paolo, Martelli, Maria-Paola, Vulliamy, Tom J., Safra, Modi, Schwartz, Schraga, Luzzatto, Lucio, Bluteau, Olivier, Soulier, Jean, Darnell, Robert B., Falini, Brunangelo, Dokal, Inderjeet, Ito, Keisuke, Clohessy, John G., Pandolfi, Pier Paolo
Publicado 2019

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

por Maroni, Giorgia, Bassal, Mahmoud A., Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A., Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castaño, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E., Fox, Sam, Levy, Rachel D., Meyerovitz, Claire V., Tramontozzi, Peter J., Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Bassères, Daniela S., Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M., Welner, Robert S., Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G., Ali, Azhar, Tenen, Daniel G., Levantini, Elena
Publicado 2021