The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

por Coates, Hudson W., Capell-Hattam, Isabelle M., Brown, Andrew J.
Publicado 2021

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

por Yoshioka, Hiromasa, Coates, Hudson W., Chua, Ngee Kiat, Hashimoto, Yuichi, Brown, Andrew J., Ohgane, Kenji
Publicado 2020

The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally

por Capell-Hattam, Isabelle M., Fenton, Nicole M., Coates, Hudson W., Sharpe, Laura J., Brown, Andrew J.
Publicado 2022

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

por Coates, Hudson W, Capell-Hattam, Isabelle M, Olzomer, Ellen M, Du, Ximing, Farrell, Rhonda, Yang, Hongyuan, Byrne, Frances L, Brown, Andrew J
Publicado 2023