Targeting an autocrine IL-6 – SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

por Mehner, Christine, Miller, Erin, Hockla, Alexandra, Coban, Mathew, Weroha, S. John, Radisky, Derek C., Radisky, Evette S.
Publicado 2020

Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma

por Mehner, Christine, Hockla, Alexandra, Coban, Mathew, Madden, Benjamin, Estrada, Rosendo, Radisky, Derek C., Radisky, Evette S.
Publicado 2022

Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain

por Coban, Mathew A., Blackburn, Patrick R., Whitelaw, Murray L., van Haelst, Mieke M., Atwal, Paldeep S., Caulfield, Thomas R.
Publicado 2020

Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10

por Raeeszadeh-Sarmazdeh, Maryam, Coban, Mathew, Mahajan, Shivansh, Hockla, Alexandra, Sankaran, Banumathi, Downey, Gregory P., Radisky, Derek C., Radisky, Evette S.
Publicado 2022

A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor

por Caulfield, Thomas R., Hayes, Karen E., Qiu, Yushi, Coban, Mathew, Seok Oh, Joon, Lane, Amy L., Yoshimitsu, Takehiko, Hazlehurst, Lori, Copland, John A., Tun, Han W.
Publicado 2020

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

por Deletti, Garrett, Green, Sajan D., Weber, Caleb, Patterson, Kristen N., Joshi, Swapnil S., Khopade, Tushar M., Coban, Mathew, Veek-Wilson, James, Caulfield, Thomas R., Viswanathan, Rajesh, Lane, Amy L.
Publicado 2023

Statistical Mechanics Metrics in Pairing and Parsing In Silico and Phenotypic Data of a Novel Genetic NFκB1 (c.T638A) Variant

por Chaudhri, Eman N., Abbott, Jessica M., Islam, Naeyma N., Weber, Caleb A., Coban, Mathew A., Bilgili, Ahmet, Squire, Jacqueline D., Mantia, Sarah, Wierenga, Klaas J., Caulfield, Thomas R.
Publicado 2023

Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

por Coban, Mathew A., Morrison, Juliet, Maharjan, Sushila, Hernandez Medina, David Hyram, Li, Wanlu, Zhang, Yu Shrike, Freeman, William D., Radisky, Evette S., Le Roch, Karine G., Weisend, Carla M., Ebihara, Hideki, Caulfield, Thomas R.
Publicado 2021

Substitution of PINK1 Gly411 modulates substrate receptivity and turnover

por Fiesel, Fabienne C, Fričová, Dominika, Hayes, Caleb S, Coban, Mathew A, Hudec, Roman, Bredenberg, Jenny M, Broadway, Benjamin J, Markham, Briana N, Yan, Tingxiang, Boneski, Paige K, Fiorino, Gabriella, Watzlawik, Jens O, Hou, Xu, McCarty, Arthur M, Lewis-Tuffin, Laura J, Zhong, Jun, Madden, Benjamin J, Ordureau, Alban, An, Heeseon, Puschmann, Andreas, Wszolek, Zbigniew K, Ross, Owen A, Harper, J Wade, Caulfield, Thomas R, Springer, Wolfdieter
Publicado 2022