Controlling for human population stratification in rare variant association studies

por Bouaziz, Matthieu, Mullaert, Jimmy, Bigio, Benedetta, Seeleuthner, Yoann, Casanova, Jean-Laurent, Alcais, Alexandre, Abel, Laurent, Cobat, Aurélie
Publicado 2021

No increased prevalence of autoantibodies neutralizing type I IFNs in idiopathic pulmonary fibrosis patients

por Philippot, Quentin, Bastard, Paul, Puel, Anne, Casanova, Jean-Laurent, Cobat, Aurélie, Laouénan, Cédric, Tardivon, Coralie, Crestani, Bruno, Borie, Raphael
Publicado 2023

Autoantibodies neutralizing type I interferons in 20% of COVID-19 deaths in a French hospital

por Chauvineau-Grenier, Angélique, Bastard, Paul, Servajean, Antoine, Gervais, Adrian, Rosain, Jérémie, Jouanguy, Emmanuelle, Cobat, Aurélie, Casanova, Jean-Laurent, Rossi, Benjamin
Publicado 2021

Autoantibodies Neutralizing Type I Interferons in 20% of COVID-19 Deaths in a French Hospital

por Chauvineau-Grenier, Angélique, Bastard, Paul, Servajean, Antoine, Gervais, Adrian, Rosain, Jérémie, Jouanguy, Emmanuelle, Cobat, Aurélie, Casanova, Jean-Laurent, Rossi, Benjamin
Publicado 2022

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

por Fava, Vinicius M., Manry, Jérémy, Cobat, Aurélie, Orlova, Marianna, Van Thuc, Nguyen, Ba, Nguyen Ngoc, Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin
Publicado 2016

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

por Manry, Jérémy, Nédélec, Yohann, Fava, Vinicius M., Cobat, Aurélie, Orlova, Marianna, Thuc, Nguyen Van, Thai, Vu Hong, Laval, Guillaume, Barreiro, Luis B., Schurr, Erwin
Publicado 2017

The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions

por Dallmann-Sauer, Monica, Fava, Vinicius M., Gzara, Chaïma, Orlova, Marianna, Van Thuc, Nguyen, Thai, Vu Hong, Alcaïs, Alexandre, Abel, Laurent, Cobat, Aurélie, Schurr, Erwin
Publicado 2020

Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

por Zhang, Qian, Bastard, Paul, Bolze, Alexandre, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Cobat, Aurélie, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Casanova, Jean-Laurent
Publicado 2020

Detection of homozygous and hemizygous complete or partial exon deletions by whole-exome sequencing

por Bigio, Benedetta, Seeleuthner, Yoann, Kerner, Gaspard, Migaud, Mélanie, Rosain, Jérémie, Boisson, Bertrand, Nasca, Carla, Puel, Anne, Bustamante, Jacinta, Casanova, Jean-Laurent, Abel, Laurent, Cobat, Aurelie
Publicado 2021

Deep resequencing identifies candidate functional genes in leprosy GWAS loci

por Fava, Vinicius M., Dallmann-Sauer, Monica, Orlova, Marianna, Correa-Macedo, Wilian, Van Thuc, Nguyen, Thai, Vu Hong, Alcaïs, Alexandre, Abel, Laurent, Cobat, Aurélie, Schurr, Erwin
Publicado 2021

Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases

por Gaschignard, Jean, Grant, Audrey Virginia, Thuc, Nguyen Van, Orlova, Marianna, Cobat, Aurélie, Huong, Nguyen Thu, Ba, Nguyen Ngoc, Thai, Vu Hong, Abel, Laurent, Schurr, Erwin, Alcaïs, Alexandre
Publicado 2016

Gene Set Signature of Reversal Reaction Type I in Leprosy Patients

por Orlova, Marianna, Cobat, Aurélie, Huong, Nguyen Thu, Ba, Nguyen Ngoc, Van Thuc, Nguyen, Spencer, John, Nédélec, Yohann, Barreiro, Luis, Thai, Vu Hong, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin
Publicado 2013

Family-based genome-wide association study of leprosy in Vietnam

por Gzara, Chaima, Dallmann-Sauer, Monica, Orlova, Marianna, Van Thuc, Nguyen, Thai, Vu Hong, Fava, Vinicius M., Bihoreau, Marie-Thérèse, Boland, Anne, Abel, Laurent, Alcaïs, Alexandre, Schurr, Erwin, Cobat, Aurélie
Publicado 2020

PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

por de Léséleuc, Louis, Orlova, Marianna, Cobat, Aurelie, Girard, Manon, Huong, Nguyen Thu, Ba, Nguyen Ngoc, Van Thuc, Nguyen, Truman, Richard, Spencer, John S., Adams, Linda, Thai, Vu Hong, Alcais, Alexandre, Schurr, Erwin
Publicado 2013

Combined Linkage and Association Studies Show that HLA Class II Variants Control Levels of Antibodies against Epstein-Barr Virus Antigens

por Pedergnana, Vincent, Syx, Laurène, Cobat, Aurélie, Guergnon, Julien, Brice, Pauline, Fermé, Christophe, Carde, Patrice, Hermine, Olivier, Pendeven, Catherine Le-, Amiel, Corinne, Taoufik, Yassine, Alcaïs, Alexandre, Theodorou, Ioannis, Besson, Caroline, Abel, Laurent
Publicado 2014

French‐style genetics v. 2.0: The “e‐CohortE” project

por Stoeklé, Henri‐Corto, Bollet, Marc, Cobat, Aurélie, Charlier, Philippe, Bloch, Oudy Ch., Flatot, Jérôme, Draghi, Clément, Tolyan, Valérie, Hervé, Christian, Desvaux, Pierre, Uzan, Laurent, Grynberg, Michaël, Alcaïs, Alexandre, Tolédano, Alain, Vogt, Guillaume
Publicado 2019

A common TMPRSS2 variant has a protective effect against severe COVID-19

por David, Alessia, Parkinson, Nicholas, Peacock, Thomas P, Pairo-Castineira, Erola, Khanna, Tarun, Cobat, Aurelie, Tenesa, Albert, Sancho-Shimizu, Vanessa, Casanova, Jean-Laurent, Abel, Laurent, Barclay, Wendy S., Baillie, J.Kenneth, Sternberg, Michael JE
Publicado 2022

Tuberculin Skin Test Negativity Is Under Tight Genetic Control of Chromosomal Region 11p14-15 in Settings With Different Tuberculosis Endemicities

por Cobat, Aurélie, Poirier, Christine, Hoal, Eileen, Boland-Auge, Anne, de La Rocque, France, Corrard, François, Grange, Ghislain, Migaud, Mélanie, Bustamante, Jacinta, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Schurr, Erwin, Alcaïs, Alexandre, Delacourt, Christophe, Abel, Laurent
Publicado 2015

An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation

por Jabot-Hanin, Fabienne, Cobat, Aurélie, Feinberg, Jacqueline, Orlova, Marianna, Niay, Jonathan, Deswarte, Caroline, Poirier, Christine, Theodorou, Ioannis, Bustamante, Jacinta, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Alcaïs, Alexandre, Hoal, Eileen G., Delacourt, Christophe, Schurr, Erwin, Abel, Laurent
Publicado 2017

Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populat...

por Jabot-Hanin, Fabienne, Cobat, Aurélie, Feinberg, Jacqueline, Grange, Ghislain, Remus, Natascha, Poirier, Christine, Boland-Auge, Anne, Besse, Céline, Bustamante, Jacinta, Boisson-Dupuis, Stéphanie, Casanova, Jean-Laurent, Schurr, Erwin, Alcaïs, Alexandre, Hoal, Eileen G., Delacourt, Christophe, Abel, Laurent
Publicado 2016