Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite

por Cobbold, Simon A., Santos, Joana M., Ochoa, Alejandro, Perlman, David H., Llinás, Manuel
Publicado 2016

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

por Lewis, Ian A., Wacker, Mark, Olszewski, Kellen L., Cobbold, Simon A., Baska, Katelynn S., Tan, Asako, Ferdig, Michael T., Llinás, Manuel
Publicado 2014

Targeting NAD(+) Metabolism in the Human Malaria Parasite Plasmodium falciparum

por O'Hara, Jessica K., Kerwin, Lewis J., Cobbold, Simon A., Tai, Jonathan, Bedell, Thomas A., Reider, Paul J., Llinás, Manuel
Publicado 2014

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum

por Dickerman, Benjamin K., Elsworth, Brendan, Cobbold, Simon A., Nie, Catherine Q., McConville, Malcolm J., Crabb, Brendan S., Gilson, Paul R.
Publicado 2016

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

por Hapuarachchi, Sanduni V., Cobbold, Simon A., Shafik, Sarah H., Dennis, Adelaide S. M., McConville, Malcolm J., Martin, Rowena E., Kirk, Kiaran, Lehane, Adele M.
Publicado 2017

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

por Kennedy, Kit, Cobbold, Simon A., Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J., McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J., Ralph, Stuart A.
Publicado 2019

The natural function of the malaria parasite’s chloroquine resistance transporter

por Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.
Publicado 2020

Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics

por Cobbold, Simon A, V Tutor, Madel, Frasse, Philip, McHugh, Emma, Karnthaler, Markus, Creek, Darren J, Odom John, Audrey, Tilley, Leann, Ralph, Stuart A, McConville, Malcolm J
Publicado 2021

Activation mechanism of PINK1

por Gan, Zhong Yan, Callegari, Sylvie, Cobbold, Simon A., Cotton, Thomas R., Mlodzianoski, Michael J., Schubert, Alexander F., Geoghegan, Niall D., Rogers, Kelly L., Leis, Andrew, Dewson, Grant, Glukhova, Alisa, Komander, David
Publicado 2021

Publisher Correction: Activation mechanism of PINK1

por Gan, Zhong Yan, Callegari, Sylvie, Cobbold, Simon A., Cotton, Thomas R., Mlodzianoski, Michael J., Schubert, Alexander F., Geoghegan, Niall D., Rogers, Kelly L., Leis, Andrew, Dewson, Grant, Glukhova, Alisa, Komander, David
Publicado 2022

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

por Dumont, Laure, Richardson, Mark B., van der Peet, Phillip, Marapana, Danushka S., Triglia, Tony, Dixon, Matthew W. A., Cowman, Alan F., Williams, Spencer J., Tilley, Leann, McConville, Malcolm J., Cobbold, Simon A.
Publicado 2019

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

por Bridgford, Jessica L., Xie, Stanley C., Cobbold, Simon A., Pasaje, Charisse Flerida A., Herrmann, Susann, Yang, Tuo, Gillett, David L., Dick, Lawrence R., Ralph, Stuart A., Dogovski, Con, Spillman, Natalie J., Tilley, Leann
Publicado 2018

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium

por Husna, Asma Ul, Wang, Nancy, Cobbold, Simon A., Newton, Hayley J., Hocking, Dianna M., Wilksch, Jonathan J., Scott, Timothy A., Davies, Mark R., Hinton, Jay C., Tree, Jai J., Lithgow, Trevor, McConville, Malcolm J., Strugnell, Richard A.
Publicado 2018

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

por Fisher, Gillian M., Cobbold, Simon A., Jezewski, Andrew, Carpenter, Emma F., Arnold, Megan, Cowell, Annie N., Tjhin, Erick T., Saliba, Kevin J., Skinner-Adams, Tina S., Lee, Marcus C. S., Odom John, Audrey, Winzeler, Elizabeth A., McConville, Malcolm J., Poulsen, Sally-Ann, Andrews, Katherine T.
Publicado 2020

Design and characterization of a heterobifunctional degrader of KEAP1

por Chen, Hao, Nguyen, Nghi H., Magtoto, Charlene M., Cobbold, Simon A., Bidgood, Grace M., Meza Guzman, Lizeth G., Richardson, Lachlan W., Corbin, Jason, Au, Amanda E., Lechtenberg, Bernhard C., Feltham, Rebecca, Sutherland, Kate D., Grohmann, Christoph, Nicholson, Sandra E., Sleebs, Brad E.
Publicado 2022

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes

por Tonkin-Hill, Gerry Q., Trianty, Leily, Noviyanti, Rintis, Nguyen, Hanh H. T., Sebayang, Boni F., Lampah, Daniel A., Marfurt, Jutta, Cobbold, Simon A., Rambhatla, Janavi S., McConville, Malcolm J., Rogerson, Stephen J., Brown, Graham V., Day, Karen P., Price, Ric N., Anstey, Nicholas M., Papenfuss, Anthony T., Duffy, Michael F.
Publicado 2018

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

por Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Publicado 2022

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

por Frank, Daniel, Garnish, Sarah E., Sandow, Jarrod J., Weir, Ashley, Liu, Lin, Clayer, Elise, Meza, Lizeth, Rashidi, Maryam, Cobbold, Simon A., Scutts, Simon R., Doerflinger, Marcel, Anderton, Holly, Lawlor, Kate E., Lalaoui, Najoua, Kueh, Andrew J., Eng, Vik Ven, Ambrose, Rebecca L., Herold, Marco J., Samson, Andre L., Feltham, Rebecca, Murphy, James M., Ebert, Gregor, Pearson, Jaclyn S., Vince, James E.
Publicado 2022