Bioisosteric Replacement as a Tool in Anti-HIV Drug Design

por Dick, Alexej, Cocklin, Simon
Publicado 2020

Recent Advances in HIV-1 Gag Inhibitor Design and Development

por Dick, Alexej, Cocklin, Simon
Publicado 2020

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions

por Dick, Alexej, Cocklin, Simon
Publicado 2021

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability

por Karadsheh, Rama, Meuser, Megan E., Cocklin, Simon
Publicado 2020

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

por Dick, Alexej, Meuser, Megan E., Cocklin, Simon
Publicado 2022

Structure, Function, and Interactions of the HIV-1 Capsid Protein

por Rossi, Eric, Meuser, Megan E., Cunanan, Camille J., Cocklin, Simon
Publicado 2021

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

por Meuser, Megan E., Murphy, Michael B., Rashad, Adel A., Cocklin, Simon
Publicado 2018

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

por Shkundina, Irina S., Gall, Alexander A., Dick, Alexej, Cocklin, Simon, Mazin, Alexander V.
Publicado 2021

Structure–Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication

por Kortagere, Sandhya, Xu, Jimmy P., Mankowski, Marie K., Ptak, Roger G., Cocklin, Simon
Publicado 2014

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitor...

por Rossi, Fiorella, Querido, Bianca, Nimmagadda, Manideepthi, Cocklin, Simon, Navas-Martín, Sonia, Martín-García, Julio
Publicado 2008

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

por Meuser, Megan E., Rashad, Adel A., Ozorowski, Gabriel, Dick, Alexej, Ward, Andrew B., Cocklin, Simon
Publicado 2019

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

por Lin, Angel, Elbezanti, Weam Othman, Schirling, Alexis, Ahmed, Adel, Van Duyne, Rachel, Cocklin, Simon, Klase, Zachary
Publicado 2021

Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis

por Williams, Patrick A., Krug, Michael S., McMillan, Emily A., Peake, Jasmine D., Davis, Tara L., Cocklin, Simon, Strochlic, Todd I.
Publicado 2016

Copper Modulates the Catalytic Activity of Protein Kinase CK2

por Chojnowski, John E., Li, Rongrong, Tsang, Tiffany, Alfaran, Fatimah H., Dick, Alexej, Cocklin, Simon, Brady, Donita C., Strochlic, Todd I.
Publicado 2022

Pandemic’s silver lining

por Ferrara, Fortunato, D’Angelo, Sara, Erasmus, M. Frank, Teixeira, André A., Leal-Lopes, Camila, Spector, Laura P., Pohl, Tom, Fanni, Adeline, Cocklin, Simon, Bradbury, Andrew R. M.
Publicado 2022

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

por Zhang, Xujie, Sun, Lin, Xu, Shujing, Shao, Xiaoyu, Li, Ziyi, Ding, Dang, Jiang, Xiangyi, Zhao, Shujie, Cocklin, Simon, Clercq, Erik De, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

por Huang, Fei, Goyal, Nadish, Sullivan, Katherine, Hanamshet, Kritika, Patel, Mikir, Mazina, Olga M., Wang, Charles X., An, W. Frank, Spoonamore, James, Metkar, Shailesh, Emmitte, Kyle A., Cocklin, Simon, Skorski, Tomasz, Mazin, Alexander V.
Publicado 2016

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

por Jiang, Xiangyi, Wu, Gaochan, Zalloum, Waleed A., Meuser, Megan E., Dick, Alexej, Sun, Lin, Chen, Chin-Ho, Kang, Dongwei, Jing, Lanlan, Jia, Ruifang, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Publicado 2019

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

por Ji, Xiangkai, Li, Jing, Sharma, Prem Prakash, Jiang, Xiangyi, Rathi, Brijesh, Gao, Zhen, Hu, Lide, Kang, Dongwei, De Clercq, Erik, Cocklin, Simon, Liu, Chuanfeng, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

por Xu, Shujing, Sun, Lin, Zalloum, Waleed A., Huang, Tianguang, Zhang, Xujie, Ding, Dang, Shao, Xiaoyu, Jiang, Xiangyi, Zhao, Fabao, Cocklin, Simon, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Publicado 2022