Genetic Sequencing of Pediatric Patients Identifies Mutations in Monogenic Inflammatory Bowel Disease Genes that Translate to Distinct Clinical Phenotypes

por Ashton, James J., Mossotto, Enrico, Stafford, Imogen S., Haggarty, Rachel, Coelho, Tracy A.F., Batra, Akshay, Afzal, Nadeem A., Mort, Matthew, Bunyan, David, Beattie, Robert Mark, Ennis, Sarah
Publicado 2020

Prediction of Crohn’s Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker

por Ashton, James J, Cheng, Guo, Stafford, Imogen S, Kellermann, Melina, Seaby, Eleanor G, Cummings,, J R Fraser, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Beattie, R Mark, Ennis, Sarah
Publicado 2022

Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in P...

por Ashton, James J, Boukas, Konstantinos, Stafford, Imogen S, Cheng, Guo, Haggarty, Rachel, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Williams, Anthony P, Polak, Marta E, Beattie, R Mark, Ennis, Sarah
Publicado 2022

Ileal Transcriptomic Analysis in Paediatric Crohn’s Disease Reveals IL17- and NOD-signalling Expression Signatures in Treatment-naïve Patients and Identifies Epithelial Cells Drivi...

por Ashton, James J, Boukas, Konstantinos, Davies, James, Stafford, Imogen S, Vallejo, Andres F, Haggarty, Rachel, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Vadgama, Bhumita, Williams, Anthony P, Beattie, R Mark, Polak, Marta E, Ennis, Sarah
Publicado 2020