NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells

por de Miranda, Lívia Bassani Lins, Lima, Keli, Coelho-Silva, Juan Luiz, Traina, Fabiola, Kobayashi, Susumu S., Machado-Neto, João Agostinho
Publicado 2022

Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis

por Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Scopim-Ribeiro, Renata, Coelho-Silva, Juan Luiz, Traina, Fabiola
Publicado 2018

Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells

por Machado-Neto, João Agostinho, Rodrigues Alves, Ana Paula Nunes, Fernandes, Jaqueline Cristina, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Fenerich, Bruna Alves, da Silva, Fernanda Borges, Scheucher, Priscila Santos, Simões, Belinda Pinto, Rego, Eduardo Magalhães, Traina, Fabiola
Publicado 2017

Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms

por Takei, Hisashi, Coelho‐Silva, Juan Luiz, Tavares Leal, Cristina, Queiroz Arantes Rocha, Adriana, Mantello Bianco, Thiago, Welner, Robert S., Mishima, Yuta, Kobayashi, Ikei S., Mullally, Ann, Lima, Keli, Machado‐Neto, João Agostinho, Kobayashi, Susumu S., Lobo de Figueiredo‐Pontes, Lorena
Publicado 2021

MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model

por Pereira-Martins, Diego A., Weinhäuser, Isabel, Coelho-Silva, Juan Luiz, França-Neto, Pedro L., Almeida, Luciana Y., Bianco, Thiago M., Silva, Cleide L., França, Rafael F., Traina, Fabiola, Rego, Eduardo M., Schuringa, Jan Jacob, Lucena-Araujo, Antonio R.
Publicado 2021

NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2(V617F)-positive myeloproliferative neoplasm cells

por Fenerich, Bruna Alves, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Coelho-Silva, Juan Luiz, Scopim-Ribeiro, Renata, Scheucher, Priscila Santos, Eide, Christopher A., Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Machado-Neto, João Agostinho, Traina, Fabiola
Publicado 2020

Metformin exerts multitarget antileukemia activity in JAK2(V617F)-positive myeloproliferative neoplasms

por Machado-Neto, João Agostinho, Fenerich, Bruna Alves, Scopim-Ribeiro, Renata, Eide, Christopher A., Coelho-Silva, Juan Luiz, Dechandt, Carlos Roberto Porto, Fernandes, Jaqueline Cristina, Rodrigues Alves, Ana Paula Nunes, Scheucher, Priscila Santos, Simões, Belinda Pinto, Alberici, Luciane Carla, de Figueiredo Pontes, Lorena Lôbo, Tognon, Cristina E., Druker, Brian J., Rego, Eduardo Magalhães, Traina, Fabiola
Publicado 2018

The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy

por Lima, Keli, Pereira-Martins, Diego Antonio, de Miranda, Lívia Bassani Lins, Coelho-Silva, Juan Luiz, Leandro, Giovana da Silva, Weinhäuser, Isabel, Cavaglieri, Rita de Cássia, Leal, Aline de Medeiros, da Silva, Wellington Fernandes, Lange, Ana Paula Alencar de Lima, Velloso, Elvira Deolinda Rodrigues Pereira, Griessinger, Emmanuel, Hilberink, Jacobien R., Ammatuna, Emanuele, Huls, Gerwin, Schuringa, Jan Jacob, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho
Publicado 2022