A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice

por Hornigold, David C., Roth, Emma, Howard, Victor, Will, Sarah, Oldham, Stephanie, Coghlan, Matthew P., Blouet, Clemence, Trevaskis, James L.
Publicado 2018

Inhalational Anesthetics Induce Neuronal Protein Aggregation and Affect ER Trafficking

por Coghlan, Matthew, Richards, Elizabeth, Shaik, Sadiq, Rossi, Pablo, Vanama, Ramesh Babu, Ahmadi, Saumel, Petroz, Christelle, Crawford, Mark, Maynes, Jason T.
Publicado 2018

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

por Biggs, Emma K., Liang, Lihuan, Naylor, Jacqueline, Madalli, Shimona, Collier, Rachel, Coghlan, Matthew P., Baker, David J., Hornigold, David C., Ravn, Peter, Reimann, Frank, Gribble, Fiona M.
Publicado 2017

Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical...

por Seyffert, Sarah, Moiz, Salwa, Coghlan, Matthew, Balozian, Patil, Nasser, Jason, Rached, Emilio Abi, Jamil, Yasser, Naqvi, Kiran, Rawlings, Lori, Perkins, Anthony J., Gao, Sujuan, Hunter, J. Downs, Khan, Sikandar, Heiderscheit, Annie, Chlan, Linda L., Khan, Babar
Publicado 2022

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

por Bowker, Nicholas, Hansford, Robert, Burgess, Stephen, Foley, Christopher N., Auyeung, Victoria P.W., Erzurumluoglu, A. Mesut, Stewart, Isobel D., Wheeler, Eleanor, Pietzner, Maik, Gribble, Fiona, Reimann, Frank, Bhatnagar, Pallav, Coghlan, Matthew P., Wareham, Nicholas J., Langenberg, Claudia
Publicado 2021

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

por Kawai, Takahiro, Sun, Bingfa, Yoshino, Hitoshi, Feng, Dan, Suzuki, Yoshiyuki, Fukazawa, Masanori, Nagao, Shunsuke, Wainscott, David B., Showalter, Aaron D., Droz, Brian A., Kobilka, Tong Sun, Coghlan, Matthew P., Willard, Francis S., Kawabe, Yoshiki, Kobilka, Brian K., Sloop, Kyle W.
Publicado 2020

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

por Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.
Publicado 2020

Structural determinants of dual incretin receptor agonism by tirzepatide

por Sun, Bingfa, Willard, Francis S., Feng, Dan, Alsina-Fernandez, Jorge, Chen, Qi, Vieth, Michal, Ho, Joseph D., Showalter, Aaron D., Stutsman, Cynthia, Ding, Liyun, Suter, Todd M., Dunbar, James D., Carpenter, John W., Mohammed, Faiz Ahmad, Aihara, Eitaro, Brown, Robert A., Bueno, Ana B., Emmerson, Paul J., Moyers, Julie S., Kobilka, Tong Sun, Coghlan, Matthew P., Kobilka, Brian K., Sloop, Kyle W.
Publicado 2022