BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis

por Weber, Kathrin, Harper, Nicholas, Schwabe, John, Cohen, Gerald M.
Publicado 2013

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells

por Butterworth, Michael, Pettitt, Andrew, Varadarajan, Shankar, Cohen, Gerald M
Publicado 2016

Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis

por Yedida, Govindaraju, Milani, Mateus, Cohen, Gerald M, Varadarajan, Shankar
Publicado 2019

Active Caspases and Cleaved Cytokeratins Are Sequestered into Cytoplasmic Inclusions in Trail-Induced Apoptosis

por MacFarlane, Marion, Merrison, Wendy, Dinsdale, David, Cohen, Gerald M.
Publicado 2000

The Inhibitor of Apoptosis Protein-Binding Domain of Smac Is Not Essential for Its Proapoptotic Activity

por Roberts, Darren L., Merrison, Wendy, MacFarlane, Marion, Cohen, Gerald M.
Publicado 2001

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

por MacFarlane, Marion, Cain, Kelvin, Sun, Xiao-Ming, Alnemri, Emad S., Cohen, Gerald M.
Publicado 1997

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

por Varadarajan, Shankar, Poornima, Paramasivan, Milani, Mateus, Gowda, Krishne, Amin, Shantu, Wang, Hong-Gang, Cohen, Gerald M.
Publicado 2015

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis

por Milani, Mateus, Byrne, Dominic P, Greaves, Georgia, Butterworth, Michael, Cohen, Gerald M, Eyers, Patrick A, Varadarajan, Shankar
Publicado 2017

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

por Milani, Mateus, Beckett, Alison J., Al-Zebeeby, Aoula, Luo, Xu, Prior, Ian A., Cohen, Gerald M., Varadarajan, Shankar
Publicado 2019

Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis

por Carter, Rachel J., Milani, Mateus, Beckett, Alison J., Liu, Shiyu, Prior, Ian A., Cohen, Gerald M., Varadarajan, Shankar
Publicado 2022

DEDD regulates degradation of intermediate filaments during apoptosis

por Lee, Justine C., Schickling, Olaf, Stegh, Alexander H., Oshima, Robert G., Dinsdale, David, Cohen, Gerald M., Peter, Marcus E.
Publicado 2002

Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis

por Varadarajan, Shankar, Tanaka, Kayoko, Smalley, Joshua L., Bampton, Edward T. W., Pellecchia, Maurizio, Dinsdale, David, Willars, Gary B., Cohen, Gerald M.
Publicado 2013

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies

por Al-Zebeeby, Aoula, Vogler, Meike, Milani, Mateus, Richards, Caitlin, Alotibi, Ahoud, Greaves, Georgia, Dyer, Martin J.S., Cohen, Gerald M., Varadarajan, Shankar
Publicado 2019

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X(L)

por Greaves, Georgia, Milani, Mateus, Butterworth, Michael, Carter, Rachel J., Byrne, Dominic P., Eyers, Patrick A., Luo, Xu, Cohen, Gerald M., Varadarajan, Shankar
Publicado 2018

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck

por Carter, Rachel J., Milani, Mateus, Butterworth, Michael, Alotibi, Ahoud, Harper, Nicholas, Yedida, Govindaraju, Greaves, Georgia, Al-Zebeeby, Aoula, Jorgensen, Andrea L., Schache, Andrew G., Risk, Janet M., Shaw, Richard J., Jones, Terry M., Sacco, Joseph J., Hurlstone, Adam, Cohen, Gerald M., Varadarajan, Shankar
Publicado 2019

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

por Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J.S., Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A., Morris, Erick, Murray, James, Geneste, Olivier
Publicado 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

por Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J., Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kumar, Sharad, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Prehn, Jochen H.M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rehm, Markus, Rizzuto, Rosario, Rodrigues, Cecilia M.P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tait, Stephen W.G., Tang, Daolin, Tavernarakis, Nektarios, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, Matthew G., Villunger, Andreas, Virgin, Herbert W., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido
Publicado 2018