Nucleated Polymerisation in the Presence of Pre-Formed Seed Filaments

por Cohen, Samuel I. A., Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J.
Publicado 2011

SAR by kinetics for drug discovery in protein misfolding diseases

por Chia, Sean, Habchi, Johnny, Michaels, Thomas C. T., Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Publicado 2018

Distinct thermodynamic signature of oligomer generation in the aggregation of the amyloid-β peptide

por Cohen, Samuel I. A., Cukalevski, Risto, Michaels, Thomas. C. T., Šarić, Anđela, Törnquist, Mattias, Vendruscolo, Michele, Dobson, Christopher M., Buell, Alexander K., Knowles, Tuomas P. J., Linse, Sara
Publicado 2018

Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation

por Rodriguez Camargo, Diana C., Sileikis, Eimantas, Chia, Sean, Axell, Emil, Bernfur, Katja, Cataldi, Rodrigo L., Cohen, Samuel I. A., Meisl, Georg, Habchi, Johnny, Knowles, Tuomas P. J., Vendruscolo, Michele, Linse, Sara
Publicado 2021

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

por Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Publicado 2019

The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers

por Cohen, Samuel I. A., Arosio, Paolo, Presto, Jenny, Kurudenkandy, Firoz Roshan, Biverstal, Henrik, Dolfe, Lisa, Dunning, Christopher, Yang, Xiaoting, Frohm, Birgitta, Vendruscolo, Michele, Johansson, Jan, Dobson, Christopher M., Fisahn, André, Knowles, Tuomas P. J., Linse, Sara
Publicado 2015

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

por Habchi, Johnny, Arosio, Paolo, Perni, Michele, Costa, Ana Rita, Yagi-Utsumi, Maho, Joshi, Priyanka, Chia, Sean, Cohen, Samuel I. A., Müller, Martin B. D., Linse, Sara, Nollen, Ellen A. A., Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Publicado 2016

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

por Cremades, Nunilo, Cohen, Samuel I.A., Deas, Emma, Abramov, Andrey Y., Chen, Allen Y., Orte, Angel, Sandal, Massimo, Clarke, Richard W., Dunne, Paul, Aprile, Francesco A., Bertoncini, Carlos W., Wood, Nicholas W., Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David
Publicado 2012

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

por Xu, Li-Qiong, Wu, Si, Buell, Alexander K., Cohen, Samuel I. A., Chen, Li-Jun, Hu, Wan-Hui, Cusack, Sarah A., Itzhaki, Laura S., Zhang, Hong, Knowles, Tuomas P. J., Dobson, Christopher M., Welland, Mark E., Jones, Gary W., Perrett, Sarah
Publicado 2013

Trodusquemine enhances Aβ(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes

por Limbocker, Ryan, Chia, Sean, Ruggeri, Francesco S., Perni, Michele, Cascella, Roberta, Heller, Gabriella T., Meisl, Georg, Mannini, Benedetta, Habchi, Johnny, Michaels, Thomas C. T., Challa, Pavan K., Ahn, Minkoo, Casford, Samuel T., Fernando, Nilumi, Xu, Catherine K., Kloss, Nina D., Cohen, Samuel I. A., Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Linse, Sara, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2019

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

por Perni, Michele, van der Goot, Annemieke, Limbocker, Ryan, van Ham, Tjakko J., Aprile, Francesco A., Xu, Catherine K., Flagmeier, Patrick, Thijssen, Karen, Sormanni, Pietro, Fusco, Giuliana, Chen, Serene W., Challa, Pavan K., Kirkegaard, Julius B., Laine, Romain F., Ma, Kai Yu, Müller, Martin B. D., Sinnige, Tessa, Kumita, Janet R., Cohen, Samuel I. A., Seinstra, Renée, Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Barbut, Denise, De Simone, Alfonso, Knowles, Tuomas P. J., Zasloff, Michael, Nollen, Ellen A. A., Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2021