The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease

por Colca, Jerry R., Scherer, Philipp E.
Publicado 2021

Metabolic Mechanisms Connecting Alzheimer’s and Parkinson’s Diseases: Potential Avenues for Novel Therapeutic Approaches

por Colca, Jerry R., Finck, Brian N.
Publicado 2022

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism

por Colca, Jerry R., McDonald, William G., McCommis, Kyle S., Finck, Brian N.
Publicado 2017

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide

por Kamm, Dakota R., Pyles, Kelly D., Sharpe, Martin C., Healy, Laura N., Colca, Jerry R., McCommis, Kyle S.
Publicado 2021

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

por Rohatgi, Nidhi, Aly, Haytham, Marshall, Connie A., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., McDaniel, Michael L.
Publicado 2013

An Evaluation of MSDC-0160, A Prototype mTOT Modulating Insulin Sensitizer, in Patients with Mild Alzheimer’s Disease

por Shah, Raj C, Matthews, Dawn C, Andrews, Randolph D, Capuano, Ana W, Fleischman, Debra A, VanderLugt, James T, Colca, Jerry R
Publicado 2014

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

por Ferguson, Daniel, Eichler, Sophie J., Yiew, Nicole K.H., Colca, Jerry R., Cho, Kevin, Patti, Gary J., Shew, Trevor M., Lutkewitte, Andrew J., Mukherjee, Sandip, McCommis, Kyle S., Niemi, Natalie M., Finck, Brian N.
Publicado 2023

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ

por Bolten, Charles W., Blanner, Patrick M., McDonald, William G., Staten, Nicholas R., Mazzarella, Richard A., Arhancet, Graciela B., Meier, Martin F., Weiss, David J., Sullivan, Patrick M., Hromockyj, Alexander E., Kletzien, Rolf F., Colca, Jerry R.
Publicado 2007

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

por Zhu, Bibo, Wei, Xiaoqin, Narasimhan, Harish, Qian, Wei, Zhang, Ruixuan, Cheon, In Su, Wu, Yue, Li, Chaofan, Jones, Russell G., Kaplan, Mark H., Vassallo, Robert A., Braciale, Thomas J., Somerville, Lindsay, Colca, Jerry R., Pandey, Akhilesh, Jackson, Patrick E. H., Mann, Barbara J., Krawczyk, Connie M., Sturek, Jeffrey M., Sun, Jie
Publicado 2023

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

por Colca, Jerry R., McDonald, William G., Cavey, Gregory S., Cole, Serena L., Holewa, Danielle D., Brightwell-Conrad, Angela S., Wolfe, Cindy L., Wheeler, Jean S., Coulter, Kristin R., Kilkuskie, Peter M., Gracheva, Elena, Korshunova, Yulia, Trusgnich, Michelle, Karr, Robert, Wiley, Sandra E., Divakaruni, Ajit S., Murphy, Anne N., Vigueira, Patrick A., Finck, Brian N., Kletzien, Rolf F.
Publicado 2013