Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes

por Colli, Maikel L., Szymczak, Florian, Eizirik, Decio L.
Publicado 2020

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

por Colli, Maikel L., Moore, Fabrice, Gurzov, Esteban N., Ortis, Fernanda, Eizirik, Decio L.
Publicado 2010

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

por Santin, Izortze, Moore, Fabrice, Colli, Maikel L., Gurzov, Esteban N., Marselli, Lorella, Marchetti, Piero, Eizirik, Decio L.
Publicado 2011

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

por Moore, Fabrice, Colli, Maikel L., Cnop, Miriam, Esteve, Mariana Igoillo, Cardozo, Alessandra K., Cunha, Daniel A., Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L.
Publicado 2009

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells

por Kaur, Simranjeet, Frørup, Caroline, Mirza, Aashiq H., Fløyel, Tina, Yarani, Reza, Colli, Maikel L., Johannesen, Jesper, Størling, Joachim, Eizirik, Decio L., Pociot, Flemming
Publicado 2022

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

por Szymczak, Florian, Cohen-Fultheim, Roni, Thomaidou, Sofia, de Brachène, Alexandra Coomans, Castela, Angela, Colli, Maikel, Marchetti, Piero, Levanon, Erez, Eizirik, Decio, Zaldumbide, Arnaud
Publicado 2022

Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells

por Ortis, Fernanda, Naamane, Najib, Flamez, Daisy, Ladrière, Laurence, Moore, Fabrice, Cunha, Daniel A., Colli, Maikel L., Thykjaer, Thomas, Thorsen, Kasper, Ørntoft, Torben F., Eizirik, Decio L.
Publicado 2010

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

por Colli, Maikel L., Nogueira, Tatiane C., Allagnat, Florent, Cunha, Daniel A., Gurzov, Esteban N., Cardozo, Alessandra K., Roivainen, Merja, Op de beeck, Anne, Eizirik, Decio L.
Publicado 2011

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

por Nogueira, Tatiane C., Paula, Flavia M., Villate, Olatz, Colli, Maikel L., Moura, Rodrigo F., Cunha, Daniel A., Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Julier, Cécile, Eizirik, Decio L.
Publicado 2013

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

por Luce, Sandrine, Guinoiseau, Sophie, Gadault, Alexis, Letourneur, Franck, Nitschke, Patrick, Bras, Marc, Vidaud, Michel, Charneau, Pierre, Larger, Etienne, Colli, Maikel L., Eizirik, Decio L., Lemonnier, François, Boitard, Christian
Publicado 2021

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells

por Alvelos, Maria Inês, Brüggemann, Mirko, Sutandy, FX Reymond, Juan-Mateu, Jonàs, Colli, Maikel Luis, Busch, Anke, Lopes, Miguel, Castela, Ângela, Aartsma-Rus, Annemieke, König, Julian, Zarnack, Kathi, Eizirik, Décio L
Publicado 2020

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells

por Szymczak, Florian, Alvelos, Maria Inês, Marín-Cañas, Sandra, Castela, Ângela, Demine, Stéphane, Colli, Maikel Luis, Op de Beeck, Anne, Thomaidou, Sofia, Marselli, Lorella, Zaldumbide, Arnaud, Marchetti, Piero, Eizirik, Décio L.
Publicado 2022

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature

por Fignani, Daniela, Licata, Giada, Brusco, Noemi, Nigi, Laura, Grieco, Giuseppina E., Marselli, Lorella, Overbergh, Lut, Gysemans, Conny, Colli, Maikel L., Marchetti, Piero, Mathieu, Chantal, Eizirik, Decio L., Sebastiani, Guido, Dotta, Francesco
Publicado 2020

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis

por Alvelos, Maria Inês, Szymczak, Florian, Castela, Ângela, Marín-Cañas, Sandra, de Souza, Bianca Marmontel, Gkantounas, Ioannis, Colli, Maikel, Fantuzzi, Federica, Cosentino, Cristina, Igoillo-Esteve, Mariana, Marselli, Lorella, Marchetti, Piero, Cnop, Miriam, Eizirik, Décio L.
Publicado 2021

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

por Eizirik, Décio L., Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L., Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I., Cnop, Miriam
Publicado 2012

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

por Colli, Maikel L., Hill, Jessica L.E., Marroquí, Laura, Chaffey, Jessica, Dos Santos, Reinaldo S., Leete, Pia, Coomans de Brachène, Alexandra, Paula, Flavia M.M., Op de Beeck, Anne, Castela, Angela, Marselli, Lorella, Krogvold, Lars, Dahl-Jorgensen, Knut, Marchetti, Piero, Morgan, Noel G., Richardson, Sarah J., Eizirik, Décio L.
Publicado 2018

The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

por Ramos-Rodríguez, Mireia, Raurell-Vila, Helena, Colli, Maikel L., Alvelos, Maria Inês, Subirana-Granés, Marc, Juan-Mateu, Jonàs, Norris, Richard, Turatsinze, Jean-Valery, Nakayasu, Ernesto S., Webb-Robertson, Bobbie-Jo M., Inshaw, Jamie R.J., Marchetti, Piero, Piemonti, Lorenzo, Esteller, Manel, Todd, John A., Metz, Thomas O., Eizirik, Décio L., Pasquali, Lorenzo
Publicado 2019

Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells

por Carré, Alexia, Zhou, Zhicheng, Perez-Hernandez, Javier, Samassa, Fatoumata, Lekka, Christiana, Manganaro, Anthony, Oshima, Masaya, Liao, Hanqing, Parker, Robert, Nicastri, Annalisa, Brandao, Barbara, Colli, Maikel L., Eizirik, Decio L., Göransson, Marcus, Morales, Orlando Burgos, Anderson, Amanda, Landry, Laurie, Kobaisi, Farah, Scharfmann, Raphael, Marselli, Lorella, Marchetti, Piero, You, Sylvaine, Nakayama, Maki, Hadrup, Sine R., Kent, Sally C., Richardson, Sarah J., Ternette, Nicola, Mallone, Roberto
Publicado 2023

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

por Colli, Maikel L., Ramos-Rodríguez, Mireia, Nakayasu, Ernesto S., Alvelos, Maria I., Lopes, Miguel, Hill, Jessica L. E., Turatsinze, Jean-Valery, Coomans de Brachène, Alexandra, Russell, Mark A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Morgan, Noel G., Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Décio L.
Publicado 2020