Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes: Application to Mycobacterium tuberculosis

por Ortega Ugalde, Sandra, Ma, Dongping, Cali, James J., Commandeur, Jan N. M.
Publicado 2019

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole

por Dekker, Stefan J, Dohmen, Floor, Vermeulen, Nico P E, Commandeur, Jan N M
Publicado 2018

A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450‐Catalyzed Substrate Conversion

por Luirink, Rosa A., Verkade‐Vreeker, Marlies C. A., Commandeur, Jan N. M., Geerke, Daan P.
Publicado 2020

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

por Vottero, Eduardo, Rea, Vanina, Lastdrager, Jeroen, Honing, Maarten, Vermeulen, Nico P. E., Commandeur, Jan N. M.
Publicado 2011

Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?

por Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris
Publicado 2019

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures

por Kool, Jeroen, Van Liempd, Sebastiaan M., Harmsen, Stefan, Schenk, Tim, Irth, Hubertus, Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado 2007

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

por Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E., Commandeur, Jan N. M., Honing, Maarten
Publicado 2016

Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining R...

por Greisch, Jean-Francois, den Boer, Maurits A., Lai, Szu-Hsueh, Gallagher, Kelly, Bondt, Albert, Commandeur, Jan, Heck, Albert J.R.
Publicado 2021

Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation

por Capoferri, Luigi, Verkade-Vreeker, Marlies C. A., Buitenhuis, Danny, Commandeur, Jan N. M., Pastor, Manuel, Vermeulen, Nico P. E., Geerke, Daan P.
Publicado 2015

Molecular weight determination of adeno‐associate virus serotype 8 virus‐like particle either carrying or lacking genome via native nES gas‐phase electrophoretic molecular mobility...

por Zoratto, Samuele, Weiss, Victor U., van der Horst, Jerre, Commandeur, Jan, Buengener, Carsten, Foettinger‐Vacha, Alexandra, Pletzenauer, Robert, Graninger, Michael, Allmaier, Guenter
Publicado 2021

Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations

por de Graaf, Chris, Oostenbrink, Chris, Keizers, Peter H. J., van Vugt-Lussenburg, Barbara M. A., Commandeur, Jan N. M., Vermeulen, Nico P. E.
Publicado 2007

Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

por Frydenvang, Karla, Verkade-Vreeker, Marlies C. A., Dohmen, Floor, Commandeur, Jan N. M., Rafiq, Maria, Mirza, Osman, Jørgensen, Flemming Steen, Geerke, Daan P.
Publicado 2019

Active-site structure, binding and redox activity of the heme–thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study

por Bonifacio, Alois, Millo, Diego, Keizers, Peter H. J., Boegschoten, Roald, Commandeur, Jan N. M., Vermeulen, Nico P. E., Gooijer, Cees, van der Zwan, Gert
Publicado 2007

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

por Ortega Ugalde, Sandra, de Koning, Coen P., Wallraven, Kerstin, Bruyneel, Ben, Vermeulen, Nico P. E., Grossmann, Tom N., Bitter, Wilbert, Commandeur, Jan N. M., Vos, J. Chris
Publicado 2018

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

por Zhang, Yongjie, den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Hiemstra, Steven, Vermeulen, Nico P. E., van de Water, Bob, Commandeur, Jan N. M., Vos, J. C.
Publicado 2018

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

por Bonifacio, Alois, Groenhof, André R., Keizers, Peter H. J., de Graaf, Chris, Commandeur, Jan N. M., Vermeulen, Nico P. E., Ehlers, Andreas W., Lammertsma, Koop, Gooijer, Cees, van der Zwan, Gert
Publicado 2007

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

por den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Toorneman, Robin M., van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J., Vermeulen, Nico P. E., Commandeur, Jan N. M., Vos, J. Chris
Publicado 2017

PB1701: REPLACING THE CURRENT METHODS IN LEUKEMIA DIAGNOSTICS WITH OPTICAL GENOME MAPPING AND CAS9-DIRECTED NANOPORE SEQUENCING.

por Commandeur-Jan, Sabrina, van den Berg- de Ruiter, Eva, Vroom, Vincent, Scheper, Arjen, Johansson, Lennart, Bosscher, Laura, Rietema, Nettie, Drok, Gineke, Sikkema-Raddatz, Birgit, Knoers, Nine, van Diemen, Cleo, de Boer, Eddy
Publicado 2023

Giving the Green Light to Photochemical Uncaging of Large Biomolecules in High Vacuum

por Hua, Yong, Strauss, Marcel, Fisher, Sergey, Mauser, Martin F. X., Manchet, Pierre, Smacchia, Martina, Geyer, Philipp, Shayeghi, Armin, Pfeffer, Michael, Eggenweiler, Tim Henri, Daly, Steven, Commandeur, Jan, Mayor, Marcel, Arndt, Markus, Šolomek, Tomáš, Köhler, Valentin
Publicado 2023

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

por Capinha, Liliana, Zhang, Yaran, Holzer, Anna-Katharina, Ückert, Anna-Katharina, Zana, Melinda, Carta, Giada, Murphy, Cormac, Baldovini, Jenna, Mazidi, Zahra, Grillari, Johannes, Dinnyes, Andras, van de Water, Bob, Leist, Marcel, Commandeur, Jan N. M., Jennings, Paul
Publicado 2022