Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds

por Perez-Rando, Marta, Dujardin, Simon, Bennett, Rachel E., Commins, Caitlin, Nibhanupudy, Tara, Hyman, Bradley T.
Publicado 2020

APOE4 derived from astrocytes leads to blood–brain barrier impairment

por Jackson, Rosemary J, Meltzer, Jonah C, Nguyen, Huong, Commins, Caitlin, Bennett, Rachel E, Hudry, Eloise, Hyman, Bradley T
Publicado 2021

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells

por Lathuiliere, Aurelien, Jo, Youhwa, Perbet, Romain, Donahue, Cameron, Commins, Caitlin, Quittot, Noé, Fan, Zhanyun, Bennett, Rachel E., Hyman, Bradley T.
Publicado 2023

Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons

por Oakley, Derek H., Klickstein, Naomi, Commins, Caitlin, Chung, Mirra, Dujardin, Simon, Bennett, Rachel E., Hyman, Bradley T., Frosch, Matthew P.
Publicado 2021

Tau propagation is dependent on the genetic background of mouse strains

por Dujardin, Simon, Fernandes, Analiese, Bannon, Riley, Commins, Caitlin, De Los Santos, Mark, Kamath, Tarun V., Hayashi, Mansuo, Hyman, Bradley T.
Publicado 2022

Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau

por Mate De Gerando, Anastasie, Welikovitch, Lindsay A., Khasnavis, Anita, Commins, Caitlin, Glynn, Calina, Chun, Joshua E., Perbet, Romain, Hyman, Bradley T.
Publicado 2023

Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases

por Kamath, Tarun V, Klickstein, Naomi, Commins, Caitlin, Fernandes, Analiese R, Oakley, Derek H, Frosch, Matthew P, Hyman, Bradley T, Dujardin, Simon
Publicado 2021

Conformational fingerprinting of tau variants and strains by Raman spectroscopy

por Devitt, George, Crisford, Anna, Rice, William, Weismiller, Hilary A., Fan, Zhanyun, Commins, Caitlin, Hyman, Bradley T., Margittai, Martin, Mahajan, Sumeet, Mudher, Amrit
Publicado 2021

An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging

por Wang, Xueying, Kastanenka, Ksenia V., Arbel-Ornath, Michal, Commins, Caitlin, Kuzuya, Akira, Lariviere, Amanda J., Krafft, Grant A., Hefti, Franz, Jerecic, Jasna, Bacskai, Brian J.
Publicado 2018

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

por DeVos, Sarah L., Corjuc, Bianca T., Oakley, Derek H., Nobuhara, Chloe K., Bannon, Riley N., Chase, Alison, Commins, Caitlin, Gonzalez, Jose A., Dooley, Patrick M., Frosch, Matthew P., Hyman, Bradley T.
Publicado 2018

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

por Nicholls, Samantha B., DeVos, Sarah L., Commins, Caitlin, Nobuhara, Chloe, Bennett, Rachel E., Corjuc, Diana L., Maury, Eduardo, Eftekharzadeh, Bahareh, Akingbade, Ololade, Fan, Zhanyun, Roe, Allyson D., Takeda, Shuko, Wegmann, Susanne, Hyman, Bradley T.
Publicado 2017

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease

por György, Bence, Lööv, Camilla, Zaborowski, Mikołaj P., Takeda, Shuko, Kleinstiver, Benjamin P., Commins, Caitlin, Kastanenka, Ksenia, Mu, Dakai, Volak, Adrienn, Giedraitis, Vilmantas, Lannfelt, Lars, Maguire, Casey A., Joung, J. Keith, Hyman, Bradley T., Breakefield, Xandra O., Ingelsson, Martin
Publicado 2018

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

por Takeda, Shuko, Wegmann, Susanne, Cho, Hansang, DeVos, Sarah L., Commins, Caitlin, Roe, Allyson D., Nicholls, Samantha B., Carlson, George A., Pitstick, Rose, Nobuhara, Chloe K., Costantino, Isabel, Frosch, Matthew P., Müller, Daniel J., Irimia, Daniel, Hyman, Bradley T.
Publicado 2015

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

por Amaral, Ana Claudia, Perez-Nievas, Beatriz G., Siao Tick Chong, Michael, Gonzalez-Martinez, Alicia, Argente-Escrig, Herminia, Rubio-Guerra, Sara, Commins, Caitlin, Muftu, Serra, Eftekharzadeh, Bahareh, Hudry, Eloise, Fan, Zhanyun, Ramanan, Prianca, Takeda, Shuko, Frosch, Matthew P., Wegmann, Susanne, Gomez-Isla, Teresa
Publicado 2021

Tau protein liquid–liquid phase separation can initiate tau aggregation

por Wegmann, Susanne, Eftekharzadeh, Bahareh, Tepper, Katharina, Zoltowska, Katarzyna M, Bennett, Rachel E, Dujardin, Simon, Laskowski, Pawel R, MacKenzie, Danny, Kamath, Tarun, Commins, Caitlin, Vanderburg, Charles, Roe, Allyson D, Fan, Zhanyun, Molliex, Amandine M, Hernandez‐Vega, Amayra, Muller, Daniel, Hyman, Anthony A, Mandelkow, Eckhard, Taylor, J Paul, Hyman, Bradley T
Publicado 2018

Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid

por Petrozziello, Tiziana, Amaral, Ana C., Dujardin, Simon, Farhan, Sali M. K., Chan, James, Trombetta, Bianca A., Kivisäkk, Pia, Mills, Alexandra N., Bordt, Evan A., Kim, Spencer E., Dooley, Patrick M., Commins, Caitlin, Connors, Theresa R., Oakley, Derek H., Ghosal, Anubrata, Gomez‐Isla, Teresa, Hyman, Bradley T., Arnold, Steven E., Spires‐Jones, Tara, Cudkowicz, Merit E., Berry, James D., Sadri‐Vakili, Ghazaleh
Publicado 2021

Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

por Wegmann, Susanne, DeVos, Sarah L., Zeitler, Bryan, Marlen, Kimberly, Bennett, Rachel E., Perez-Rando, Marta, MacKenzie, Danny, Yu, Qi, Commins, Caitlin, Bannon, Riley N., Corjuc, Bianca T., Chase, Alison, Diez, Lisa, Nguyen, Hoang-Oanh B., Hinkley, Sarah, Zhang, Lei, Goodwin, Alicia, Ledeboer, Annemarie, Lam, Stephen, Ankoudinova, Irina, Tran, Hung, Scarlott, Nicholas, Amora, Rainier, Surosky, Richard, Miller, Jeffrey C., Robbins, Ashley B., Rebar, Edward J., Urnov, Fyodor D., Holmes, Michael C., Pooler, Amy M., Riley, Brigit, Zhang, H. Steve, Hyman, Bradley T.
Publicado 2021