43. BUILDING ON GENETICS AND PATHOPHYSIOLOGY OF SCHIZOPHRENIA TO GUIDE DISCOVERY OF NEW TREATMENTS

por Conn, P Jeffrey
Publicado 2018

Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease

por Luessen, Deborah J., Conn, P. Jeffrey
Publicado 2022

Neurobiological Insights from mGlu Receptor Allosteric Modulation

por O’Brien, Daniel E, Conn, P Jeffrey
Publicado 2015

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

por Maksymetz, James, Moran, Sean P., Conn, P. Jeffrey
Publicado 2017

Activation of M(1) and M(4) muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia

por Foster, Daniel J, Choi, Derrick L, Conn, P Jeffrey, Rook, Jerri M
Publicado 2014

43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA

por Conn, P Jeffrey, Yohn, Samantha, Stansley, Branden, Foster, Dan, Plumley, Hyekyung, Lindsley, Craig
Publicado 2018

Correction: MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning

por Bikbaev, Arthur, Neyman, Sergey, Ngomba, Richard Teke, Conn, P. Jeffrey, Nicoletti, Ferdinando, Manahan-Vaughan, Denise
Publicado 2008

Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function

por Joffe, Max E., Santiago, Chiaki I., Engers, Julie L., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2017

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

por Senter, Rebecca K., Ghoshal, Ayan, Walker, Adam G., Xiang, Zixiu, Niswender, Colleen M., Conn, P. Jeffrey
Publicado 2016

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

por Hammond, Alexis S., Rodriguez, Alice L., Townsend, Steven D., Niswender, Colleen M., Gregory, Karen J., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2010

Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Den...

por Bauer, James P., Rader, Sarah L., Joffe, Max E., Kwon, Wooseok, Quay, Juliana, Seanez, Leann, Zhou, Chengwen, Conn, P. Jeffrey, Lewis, Alan S.
Publicado 2021

Probing the binding site of novel selective positive allosteric modulators at the M(1) muscarinic acetylcholine receptor

por Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur
Publicado 2018

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling

por Xiang, Zixiu, Lv, Xiaohui, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey
Publicado 2019

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

por Vermudez, Sheryl Anne D., Gogliotti, Rocco G., Arthur, Bright, Buch, Aditi, Morales, Clarissa, Moxley, Yuta, Rajpal, Hemangi, Conn, P. Jeffrey, Niswender, Colleen M.
Publicado 2021

Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning

por Xu, Jian, Zhu, Yongling, Kraniotis, Stephen, He, Qionger, Marshall, John J., Nomura, Toshihiro, Stauffer, Shaun R., Lindsley, Craig W., Conn, P. Jeffrey, Contractor, Anis
Publicado 2013

Mutual activation of glutamatergic mGlu(4) and muscarinic M(4) receptors reverses schizophrenia-related changes in rodents

por Cieślik, Paulina, Woźniak, Monika, Rook, Jerri M., Tantawy, Mohammed N., Conn, P. Jeffrey, Acher, Francine, Tokarski, Krzysztof, Kusek, Magdalena, Pilc, Andrzej, Wierońska, Joanna M.
Publicado 2018

Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

por Mueller, Ralf, Rodriguez, Alice L., Dawson, Eric S., Butkiewicz, Mariusz, Nguyen, Thuy T., Oleszkiewicz, Stephen, Bleckmann, Annalen, Weaver, C. David, Lindsley, Craig W., Conn, P. Jeffrey, Meiler, Jens
Publicado 2010

Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands

por Presley, Christopher C., Perry, Charles K., Childress, Elizabeth S., Mulder, Matthew J., Luscombe, Vincent B., Rodriguez, Alice L., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W.
Publicado 2019

mGlu(1) potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits

por Maksymetz, James, Byun, Nellie E., Luessen, Deborah J., Li, Brianna, Barry, Robert L., Gore, John C., Niswender, Colleen M., Lindsley, Craig W., Joffe, Max E., Conn, P. Jeffrey
Publicado 2021

Discovery of “Molecular Switches” within a Series of mGlu(5) Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from a...

por Barbaro, Lisa, Rodriguez, Alice L., Blevins, Ashlyn N., Dickerson, Jonathan W., Billard, Natasha, Boutaud, Olivier, Rook, Jerri L., Niswender, Colleen M., Conn, P.Jeffrey, Engers, Darren W., Lindsley, Craig W.
Publicado 2021