Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues

por Conner, Kip P., Pastuskovas, Cinthia V., Soto, Marcus, Thomas, Veena A., Wagner, Mylo, Rock, Dan A.
Publicado 2020

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins

por Ghelani, Aazam, Bates, Darren, Conner, Kip, Wu, Min-Zu, Lu, Jiamiao, Hu, Yi-Ling, Li, Chi-Ming, Chaudhry, Ashutosh, Sohn, Sue J.
Publicado 2020

Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s Is Isoform Dependent

por Conner, Kip P., Schimpf, Alina M., Cruce, Alex A., McLean, Kirsty J., Munro, Andrew W., Frank, Daniel J., Krzyaniak, Matthew D., Ortiz de Montellano, Paul, Bowman, Michael K., Atkins, William M.
Publicado 2014

Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice

por Liu, Shufang, Humphreys, Sara C., Cook, Kevin D., Conner, Kip P., Correia, Ana R., Jacobitz, Alex W., Yang, Melissa, Primack, Ronya, Soto, Marcus, Padaki, Rupa, Lubomirski, Mariusz, Smith, Richard, Mock, Marissa, Thomas, Veena A.
Publicado 2023

Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

por Mock, Marissa, Jacobitz, Alex W., Langmead, Christopher James, Sudom, Athena, Yoo, Daniel, Humphreys, Sara C., Alday, Mai, Alekseychyk, Larysa, Angell, Nicolas, Bi, Vivian, Catterall, Hannah, Chen, Chen-Chun, Chou, Hui-Ting, Conner, Kip P., Cook, Kevin D., Correia, Ana R., Dykstra, Andrew, Ghimire-Rijal, Sudipa, Graham, Kevin, Grandsard, Peter, Huh, Joon, Hui, John O., Jain, Mani, Jann, Victoria, Jia, Lei, Johnstone, Sheree, Khanal, Neelam, Kolvenbach, Carl, Narhi, Linda, Padaki, Rupa, Pelegri-O’Day, Emma M., Qi, Wei, Razinkov, Vladimir, Rice, Austin J., Smith, Richard, Spahr, Christopher, Stevens, Jennitte, Sun, Yax, Thomas, Veena A., van Driesche, Sarah, Vernon, Robert, Wagner, Victoria, Walker, Kenneth W., Wei, Yangjie, Winters, Dwight, Yang, Melissa, Campuzano, Iain D. G.
Publicado 2023