UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

por Mondal, Milon, Conole, Daniel, Nautiyal, Jaya, Tate, Edward W.
Publicado 2021

Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

por Conole, Daniel, Mondal, Milon, Majmudar, Jaimeen D., Tate, Edward W.
Publicado 2019

Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands

por Conole, Daniel, Myers, Samuel H., Mota, Filipa, Hobbs, Adrian J., Selwood, David L.
Publicado 2018

A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C

por Smith, Robert J., Perez-Ternero, Cristina, Conole, Daniel, Martin, Capucine, Myers, Samuel H., Hobbs, Adrian J., Selwood, David L.
Publicado 2022

Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules

por Conole, Daniel, Chou, Yi‐Tai, Patsiarika, Anastasia, Nwabo, Valery, Dimitriou, Eleni, Soudy, Christelle, Mota, Filipa, Djordjevic, Snezana, Selwood, David L.
Publicado 2020

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

por Choi, Peter J., Conole, Daniel, Sutherland, Hamish S., Blaser, Adrian, Tong, Amy S.T., Cooper, Christopher B., Upton, Anna M., Palmer, Brian D., Denny, William A.
Publicado 2020

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

por Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Publicado 2019

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

por Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha U., Denny, William A., Palmer, Brian D.
Publicado 2018

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

por Stefaniak, Jakub, Lewis, Andrew M., Conole, Daniel, Galan, Sébastien R. G., Bataille, Carole J. R., Wynne, Graham M., Castaldi, M. Paola, Lundbäck, Thomas, Russell, Angela J., Huber, Kilian V. M.
Publicado 2018

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

por Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Publicado 2019

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

por Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Sutherland, Hamish S., Choi, Peter J., Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Denny, William A., Palmer, Brian D.
Publicado 2020

Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis

por Sutherland, Hamish S., Lu, Guo-Liang, Tong, Amy S.T., Conole, Daniel, Franzblau, Scott G., Upton, Anna M., Lotlikar, Manisha U., Cooper, Christopher B., Palmer, Brian D., Choi, Peter J., Denny, William A.
Publicado 2022

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

por Tong, Amy S. T., Choi, Peter J., Blaser, Adrian, Sutherland, Hamish S., Tsang, Sophia K. Y., Guillemont, Jerome, Motte, Magali, Cooper, Christopher B., Andries, Koen, Van den Broeck, Walter, Franzblau, Scott G., Upton, Anna M., Denny, William A., Palmer, Brian D., Conole, Daniel
Publicado 2017

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

por Zhang, Qisi, Kounde, Cyrille S., Mondal, Milon, Greenfield, Jake L., Baker, Jennifer R., Kotelnikov, Sergei, Ignatov, Mikhail, Tinworth, Christopher P., Zhang, Leran, Conole, Daniel, De Vita, Elena, Kozakov, Dima, McCluskey, Adam, Harling, John D., Fuchter, Matthew J., Tate, Edward W.
Publicado 2022

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

por Simões, Bruno M., Santiago-Gómez, Angélica, Chiodo, Chiara, Moreira, Tiago, Conole, Daniel, Lovell, Scott, Alferez, Denis, Eyre, Rachel, Spence, Katherine, Sarmiento-Castro, Aida, Kohler, Bertram, Morisset, Ludivine, Lanzino, Marilena, Andò, Sebastiano, Marangoni, Elisabetta, Sims, Andrew H., Tate, Edward W., Howell, Sacha J., Clarke, Robert B.
Publicado 2020

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

por Jackson, Thomas R., Vuorinen, Aini, Josa-Culleré, Laia, Madden, Katrina S., Conole, Daniel, Cogswell, Thomas J., Wilkinson, Isabel V.L., Kettyle, Laura M., Zhang, Douzi, O’Mahony, Alison, Gracias, Deanne, McCall, Lorna, Westwood, Robert, Terstappen, Georg C., Davies, Stephen G., Tate, Edward W., Wynne, Graham M., Vyas, Paresh, Russell, Angela J., Milne, Thomas A.
Publicado 2022