Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

por Prescott, Jack A., Cook, Simon J.
Publicado 2018

Macroautophagy is repressed during mitosis – seeing is believing

por Odle, Richard I., Cook, Simon J.
Publicado 2020

Inhibition of RAF dimers: it takes two to tango

por Cook, Frazer A., Cook, Simon J.
Publicado 2021

ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?

por Cook, Simon J., Lochhead, Pamela A.
Publicado 2022

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death

por Darling, Nicola J., Balmanno, Kathryn, Cook, Simon J.
Publicado 2017

Resistance to ERK1/2 pathway inhibitors; sweet spots, fitness deficits and drug addiction

por Sale, Matthew J., Balmanno, Kathryn, Cook, Simon J.
Publicado 2019

Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…

por Cook, Simon J., Tucker, Julie A., Lochhead, Pamela A.
Publicado 2020

Inhibitory feedback control of NF-κB signalling in health and disease

por Prescott, Jack A., Mitchell, Jennifer P., Cook, Simon J.
Publicado 2021

MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling

por Evans, Catherine, Cook, Simon J., Coleman, Michael P., Gilley, Jonathan
Publicado 2013

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling

por Cook, Simon J., Stuart, Kate, Gilley, Rebecca, Sale, Matthew J.
Publicado 2017

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

por Prescott, Jack A., Balmanno, Kathryn, Mitchell, Jennifer P., Okkenhaug, Hanneke, Cook, Simon J.
Publicado 2022

The empirical basis for modelling glacial erosion rates

por Cook, Simon J., Swift, Darrel A., Kirkbride, Martin P., Knight, Peter G., Waller, Richard I.
Publicado 2020

Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance

por Channathodiyil, Prasanna, May, Kieron, Segonds-Pichon, Anne, Smith, Paul D, Cook, Simon J, Houseley, Jonathan
Publicado 2022

Accelerated mass loss of Himalayan glaciers since the Little Ice Age

por Lee, Ethan, Carrivick, Jonathan L., Quincey, Duncan J., Cook, Simon J., James, William H. M., Brown, Lee E.
Publicado 2021

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

por Balmanno, Kathryn, Kidger, Andrew M., Byrne, Dominic P., Sale, Matthew J., Nassman, Nejma, Eyers, Patrick A., Cook, Simon J.
Publicado 2023

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

por Cambuli, Francesco, Murray, Alexander, Dean, Wendy, Dudzinska, Dominika, Krueger, Felix, Andrews, Simon, Senner, Claire E., Cook, Simon J., Hemberger, Myriam
Publicado 2014

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release

por Dautova, Yana, Kapustin, Alexander N., Pappert, Kevin, Epple, Matthias, Okkenhaug, Hanneke, Cook, Simon J., Shanahan, Catherine M., Bootman, Martin D., Proudfoot, Diane
Publicado 2018

(V600E)Braf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16(INK4a)

por Carragher, Linda A S, Snell, Kimberley R, Giblett, Susan M, Aldridge, Victoria S S, Patel, Bipin, Cook, Simon J, Winton, Doug J, Marais, Richard, Pritchard, Catrin A
Publicado 2010

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

por Najas, Sònia, Arranz, Juan, Lochhead, Pamela A., Ashford, Anne L., Oxley, David, Delabar, Jean M., Cook, Simon J., Barallobre, María José, Arbonés, Maria L.
Publicado 2015

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

por Odle, Richard I., Walker, Simon A., Oxley, David, Kidger, Andrew M., Balmanno, Kathryn, Gilley, Rebecca, Okkenhaug, Hanneke, Florey, Oliver, Ktistakis, Nicholas T., Cook, Simon J.
Publicado 2020