Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity

por Thomas, Ross S, Sarwar, Naveed, Phoenix, Fladia, Coombes, R Charles, Ali, Simak
Publicado 2008

A Review of Circulating Tumour Cell Enrichment Technologies

por Rushton, Amelia J., Nteliopoulos, Georgios, Shaw, Jacqueline A., Coombes, R. Charles
Publicado 2021

FOXA1 is a determinant of drug resistance in breast cancer cells

por Kumar, Uttom, Ardasheva, Anastasia, Mahmud, Zimam, Coombes, R. Charles, Yagüe, Ernesto
Publicado 2021

CDK7 inhibitors as anticancer drugs

por Sava, Georgina P., Fan, Hailing, Coombes, R. Charles, Buluwela, Lakjaya, Ali, Simak
Publicado 2020

Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

por Alao, John P, Stavropoulou, Alexandra V, Lam, Eric W-F, Coombes, R Charles
Publicado 2006

Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells

por Lombardo, Ylenia, Faronato, Monica, Filipovic, Aleksandra, Vircillo, Valentina, Magnani, Luca, Coombes, R Charles
Publicado 2014

Expression of Cancer/Testis genes in ductal carcinoma in situ and benign lesions of the breast

por Caballero, Otavia L., Shousha, Sami, Zhao, Qi, Simpson, Andrew J.G., Coombes, R. Charles, Neville, A. Munro
Publicado 2013

Single Particle Automated Raman Trapping Analysis of Breast Cancer Cell-Derived Extracellular Vesicles as Cancer Biomarkers

por Penders, Jelle, Nagelkerke, Anika, Cunnane, Eoghan M., Pedersen, Simon V., Pence, Isaac J., Coombes, R. Charles, Stevens, Molly M.
Publicado 2021

NY-ESO-1 expression in DCIS: A new predictor of good prognosis

por Coombes, R. Charles, Caballero, Otavia L., Shousha, Sami, Ghaem-Maghami, Sadaf, Woodley-Barker, Laura, Wilhelm-Benartzi, Charlotte S., Neville, A. Munro
Publicado 2017

The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines

por Alao, John P, Gamble, Simon C, Stavropoulou, Alexandra V, Pomeranz, Karen M, Lam, Eric W-F, Coombes, R Charles, Vigushin, David M
Publicado 2006

Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation

por Fraser, Scott P., Ozerlat-Gunduz, Iley, Brackenbury, William J., Fitzgerald, Elizabeth M., Campbell, Thomas M., Coombes, R. Charles, Djamgoz, Mustafa B. A.
Publicado 2014

CK1δ modulates the transcriptional activity of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions

por Giamas, Georgios, Castellano, Leandro, Feng, Qin, Knippschild, Uwe, Jacob, Jimmy, Thomas, Ross S., Coombes, R. Charles, Smith, Carolyn L., Jiao, Long R., Stebbing, Justin
Publicado 2009

The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study

por Stebbing, Justin, Payne, Rachel, Reise, Justine, Frampton, Adam E., Avery, Miranda, Woodley, Laura, Di Leo, Angelo, Pestrin, Marta, Krell, Jonathan, Coombes, R. Charles
Publicado 2013

Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

por Blighe, Kevin, Kenny, Laura, Patel, Naina, Guttery, David S., Page, Karen, Gronau, Julian H., Golshani, Cyrus, Stebbing, Justin, Coombes, R. Charles, Shaw, Jacqueline A.
Publicado 2014

The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation

por Alexandrou, George, Mantikas, Katerina-Theresa, Allsopp, Rebecca, Yapeter, Calista Adele, Jahin, Myesha, Melnick, Taryn, Ali, Simak, Coombes, R. Charles, Toumazou, Christofer, Shaw, Jacqueline A., Kalofonou, Melpomeni
Publicado 2023

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through notch hyper-activation

por Faronato, Monica, Nguyen, Van T.M., Patten, Darren K., Lombardo, Ylenia, Steel, Jennifer H., Patel, Naina, Woodley, Laura, Shousha, Sami, Pruneri, Giancarlo, Coombes, R. Charles, Magnani, Luca
Publicado 2015

Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Rep...

por Szijgyarto, Zsolt, Flach, Koen D., Opdam, Mark, Palmieri, Carlo, Linn, Sabine C., Wesseling, Jelle, Ali, Simak, Bliss, Judith M., Cheang, Maggie Chon U., Zwart, Wilbert, Coombes, R. Charles
Publicado 2019

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

por Hong, Sung Pil, Chan, Thalia E., Lombardo, Ylenia, Corleone, Giacomo, Rotmensz, Nicole, Bravaccini, Sara, Rocca, Andrea, Pruneri, Giancarlo, McEwen, Kirsten R., Coombes, R. Charles, Barozzi, Iros, Magnani, Luca
Publicado 2019

Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer

por Asaduzzaman, Muhammad, Constantinou, Stephanie, Min, Haoxiang, Gallon, John, Lin, Meng-Lay, Singh, Poonam, Raguz, Selina, Ali, Simak, Shousha, Sami, Coombes, R. Charles, Lam, Eric W.-F., Hu, Yunhui, Yagüe, Ernesto
Publicado 2017

Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB

por Periyasamy, Manikandan, Singh, Anup K, Gemma, Carolina, Farzan, Raed, Allsopp, Rebecca C, Shaw, Jacqueline A, Charmsaz, Sara, Young, Leonie S, Cunnea, Paula, Coombes, R Charles, Győrffy, Balázs, Buluwela, Lakjaya, Ali, Simak
Publicado 2021