Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy

por Coorens, Tim H. H., Collord, Grace, Treger, Taryn D., Adams, Stuart, Mitchell, Emily, Newman, Barbara, Getz, Gad, Godfrey, Anna L., Bartram, Jack, Behjati, Sam
Publicado 2023

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

por Khabirova, Eleonora, Jardine, Laura, Coorens, Tim H. H., Webb, Simone, Treger, Taryn D., Engelbert, Justin, Porter, Tarryn, Prigmore, Elena, Collord, Grace, Piapi, Alice, Teichmann, Sarah A., Inglott, Sarah, Williams, Owen, Heidenreich, Olaf, Young, Matthew D., Straathof, Karin, Bomken, Simon, Bartram, Jack, Haniffa, Muzlifah, Behjati, Sam
Publicado 2022

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

por Molè, Matteo A., Coorens, Tim H. H., Shahbazi, Marta N., Weberling, Antonia, Weatherbee, Bailey A. T., Gantner, Carlos W., Sancho-Serra, Carmen, Richardson, Lucy, Drinkwater, Abbie, Syed, Najma, Engley, Stephanie, Snell, Philip, Christie, Leila, Elder, Kay, Campbell, Alison, Fishel, Simon, Behjati, Sam, Vento-Tormo, Roser, Zernicka-Goetz, Magdalena
Publicado 2021

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

por Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.
Publicado 2021

APOBEC mutagenesis is a common process in normal human small intestine

por Wang, Yichen, Robinson, Philip S., Coorens, Tim H. H., Moore, Luiza, Lee-Six, Henry, Noorani, Ayesha, Sanders, Mathijs A., Jung, Hyunchul, Katainen, Riku, Heuschkel, Robert, Brunton-Sim, Roxanne, Weston, Robyn, Read, Debbie, Nobbs, Beverley, Fitzgerald, Rebecca C., Saeb-Parsy, Kourosh, Martincorena, Iñigo, Campbell, Peter J., Rushbrook, Simon, Zilbauer, Matthias, Buczacki, Simon James Alexander, Stratton, Michael R.
Publicado 2023

Targetable NOTCH1 rearrangements in reninoma

por Treger, Taryn D., Lawrence, John E. G., Anderson, Nathaniel D., Coorens, Tim H. H., Letunovska, Aleksandra, Abby, Emilie, Lee-Six, Henry, Oliver, Thomas R. W., Al-Saadi, Reem, Tullus, Kjell, Morcrette, Guillaume, Hutchinson, J. Ciaran, Rampling, Dyanne, Sebire, Neil, Pritchard-Jones, Kathy, Young, Matthew D., Mitchell, Thomas J., Jones, Philip H., Tran, Maxine, Behjati, Sam, Chowdhury, Tanzina
Publicado 2023

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

por Custers, Lars, Khabirova, Eleonora, Coorens, Tim H. H., Oliver, Thomas R. W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, Drost, Jarno
Publicado 2021

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

por Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Publicado 2022

Clonal diversification and histogenesis of malignant germ cell tumours

por Oliver, Thomas R. W., Chappell, Lia, Sanghvi, Rashesh, Deighton, Lauren, Ansari-Pour, Naser, Dentro, Stefan C., Young, Matthew D., Coorens, Tim H. H., Jung, Hyunchul, Butler, Tim, Neville, Matthew D. C., Leongamornlert, Daniel, Sanders, Mathijs A., Hooks, Yvette, Cagan, Alex, Mitchell, Thomas J., Cortes-Ciriano, Isidro, Warren, Anne Y., Wedge, David C., Heer, Rakesh, Coleman, Nicholas, Murray, Matthew J., Campbell, Peter J., Rahbari, Raheleh, Behjati, Sam
Publicado 2022

The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils

por Stammnitz, Maximilian R., Coorens, Tim H.H., Gori, Kevin C., Hayes, Dane, Fu, Beiyuan, Wang, Jinhong, Martin-Herranz, Daniel E., Alexandrov, Ludmil B., Baez-Ortega, Adrian, Barthorpe, Syd, Beck, Alexandra, Giordano, Francesca, Knowles, Graeme W., Kwon, Young Mi, Hall, George, Price, Stacey, Pye, Ruth J., Tubio, Jose M.C., Siddle, Hannah V.T., Sohal, Sukhwinder Singh, Woods, Gregory M., McDermott, Ultan, Yang, Fengtang, Garnett, Mathew J., Ning, Zemin, Murchison, Elizabeth P.
Publicado 2018

Clonal dynamics of haematopoiesis across the human lifespan

por Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J., Mende, Nicole, Calderbank, Emily F., Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim H. H., Spencer, David H., Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A., Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George S., Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R., Kent, David G., Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Anthony R., Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J.
Publicado 2022

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

por Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Publicado 2022

Somatic mutation rates scale with lifespan across mammals

por Cagan, Alex, Baez-Ortega, Adrian, Brzozowska, Natalia, Abascal, Federico, Coorens, Tim H. H., Sanders, Mathijs A., Lawson, Andrew R. J., Harvey, Luke M. R., Bhosle, Shriram, Jones, David, Alcantara, Raul E., Butler, Timothy M., Hooks, Yvette, Roberts, Kirsty, Anderson, Elizabeth, Lunn, Sharna, Flach, Edmund, Spiro, Simon, Januszczak, Inez, Wrigglesworth, Ethan, Jenkins, Hannah, Dallas, Tilly, Masters, Nic, Perkins, Matthew W., Deaville, Robert, Druce, Megan, Bogeska, Ruzhica, Milsom, Michael D., Neumann, Björn, Gorman, Frank, Constantino-Casas, Fernando, Peachey, Laura, Bochynska, Diana, Smith, Ewan St. John, Gerstung, Moritz, Campbell, Peter J., Murchison, Elizabeth P., Stratton, Michael R., Martincorena, Iñigo
Publicado 2022

Single cell derived mRNA signals across human kidney tumors

por Young, Matthew D., Mitchell, Thomas J., Custers, Lars, Margaritis, Thanasis, Morales-Rodriguez, Francisco, Kwakwa, Kwasi, Khabirova, Eleonora, Kildisiute, Gerda, Oliver, Thomas R. W., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., Comitani, Federico, Piapi, Alice, Bugallo-Blanco, Eva, Thevanesan, Christine, Burke, Christina, Prigmore, Elena, Ambridge, Kirsty, Roberts, Kenny, Braga, Felipe A. Vieira, Coorens, Tim H. H., Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D., Gnanapragasam, Vincent J., Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M., Achermann, John C., He, Xiaoling, Barker, Roger A., Shlien, Adam, Bayraktar, Omer A., Teichmann, Sarah A., Holstege, Frank C., Meyer, Kerstin B., Drost, Jarno, Straathof, Karin, Behjati, Sam
Publicado 2021