Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer

por Gregory, Georgina L., Copple, Ian M.
Publicado 2022

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

por Mutter, Fiona E., Park, B. Kevin, Copple, Ian M.
Publicado 2015

NRF2 as an Emerging Therapeutic Target

por Copple, Ian M., Dinkova-Kostova, Albena T., Kensler, Thomas W., Liby, Karen T., Wigley, W. Christian
Publicado 2017

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

por Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.
Publicado 2017

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

por Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin
Publicado 2010

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

por Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin
Publicado 2014

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

por Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin
Publicado 2011

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis

por Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., Odermatt, Alex
Publicado 2018

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

por Shelton, Luke M., Lister, Adam, Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael H. L., Rowe, Cliff, Ricci, Emanuele, Ressel, Lorenzo, Fang, Yongxiang, Demougin, Philippe, Vukojevic, Vanja, O’Neill, Paul M., Goldring, Christopher E., Kitteringham, Neil R., Park, B. Kevin, Odermatt, Alex, Copple, Ian M.
Publicado 2015

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

por Evans, Jonathan P., Winiarski, Boleslaw K., Sutton, Paul A., Jones, Robert P., Ressel, Lorenzo, Duckworth, Carrie A., Pritchard, D. Mark, Lin, Zhi-Xiu, Vicky, Fretwell L., Tweedle, Elizabeth M., Costello, Eithne, Goldring, Christopher E., Copple, Ian M., Park, B. Kevin, Palmer, Daniel H., Kitteringham, Neil R.
Publicado 2018

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

por Evans, Jonathan P., Winiarski, Boleslaw K., Sutton, Paul A., Jones, Robert P., Ressel, Lorenzo, Duckworth, Carrie A., Pritchard, D. Mark, Lin, Zhi-Xiu, Fretwell, Vicky L., Tweedle, Elizabeth M., Costello, Eithne, Goldring, Christopher E., Copple, Ian M., Park, B. Kevin, Palmer, Daniel H., Kitteringham, Neil R.
Publicado 2019

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

por Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., Park, B. Kevin
Publicado 2018

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

por Olayanju, Adedamola, Copple, Ian M., Bryan, Holly K., Edge, George T., Sison, Rowena L., Wong, Min Wei, Lai, Zheng-Quan, Lin, Zhi-Xiu, Dunn, Karen, Sanderson, Christopher M., Alghanem, Ahmad F., Cross, Michael J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Malik, Hassan Z., Kitteringham, Neil R., Goldring, Christopher E., Park, B. Kevin
Publicado 2015

A systems approach reveals species differences in hepatic stress response capacity

por Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M
Publicado 2023

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

por Ghallab, Ahmed, Hassan, Reham, Hofmann, Ute, Friebel, Adrian, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Myllys, Maiju, Reinders, Joerg, Overbeck, Nina, Sezgin, Selahaddin, Zühlke, Sebastian, Seddek, Abdel-latif, Murad, Walaa, Brecklinghaus, Tim, Kappenberg, Franziska, Rahnenführer, Jörg, González, Daniela, Goldring, Christopher, Copple, Ian M., Marchan, Rosemarie, Longerich, Thomas, Vucur, Mihael, Luedde, Tom, Urban, Stephan, Canbay, Ali, Schreiter, Thomas, Trauner, Michael, Akakpo, Jephte Y., Olyaee, Mojtaba, Curry, Steven C., Sowa, Jan-Peter, Jaeschke, Hartmut, Hoehme, Stefan, Hengstler, Jan G.
Publicado 2022

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

por O'Neill, Paul M., Amewu, Richard K., Charman, Susan A., Sabbani, Sunil, Gnädig, Nina F., Straimer, Judith, Fidock, David A., Shore, Emma R., Roberts, Natalie L., Wong, Michael H.-L., Hong, W. David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M., Campbell, Simon, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Palmer, Michael J., Copple, Ian M., Mercer, Amy E., Ruecker, Andrea, Delves, Michael J., Sinden, Robert E., Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H. M., Zeeman, Anne-Marie, Nixon, Gemma L., Biagini, Giancarlo A., Ward, Stephen A.
Publicado 2017