Complex Loop Dynamics Underpin Activity, Specificity, and Evolvability in the (βα)(8) Barrel Enzymes of Histidine and Tryptophan Biosynthesis

por Romero-Rivera, Adrian, Corbella, Marina, Parracino, Antonietta, Patrick, Wayne M., Kamerlin, Shina Caroline Lynn
Publicado 2022

The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition

por Corbella, Marina, Liao, Qinghua, Moreira, Cátia, Parracino, Antonietta, Kasson, Peter M., Kamerlin, Shina Caroline Lynn
Publicado 2021

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

por Fisher, Gemma, Corbella, Marina, Alphey, Magnus S., Nicholson, John, Read, Benjamin J., Kamerlin, Shina C. L., da Silva, Rafael G.
Publicado 2022

Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases

por Shen, Ruidan, Crean, Rory M., Olsen, Keith J., Corbella, Marina, Calixto, Ana R., Richan, Teisha, Brandão, Tiago A. S., Berry, Ryan D., Tolman, Alex, Loria, J. Patrick, Johnson, Sean J., Kamerlin, Shina C. L., Hengge, Alvan C.
Publicado 2022