The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

por Trigo, Diogo, Goncalves, Maria B., Corcoran, Jonathan P. T.
Publicado 2019

Recent advances in the design of RAR α and RAR β agonists as orally bioavailable drugs. A review

por Borthwick, Alan D., Goncalves, Maria B., Corcoran, Jonathan P.T.
Publicado 2020

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

por Goncalves, Maria B, Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P T
Publicado 2013

A retinoic acid receptor β agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord

por Agudo, Marta, Yip, Ping, Davies, Meirion, Bradbury, Elizabeth, Doherty, Patrick, McMahon, Stephen, Maden, Malcolm, Corcoran, Jonathan P.T.
Publicado 2010

Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells

por Goncalves, Maria B., Wu, Yue, Clarke, Earl, Grist, John, Hobbs, Carl, Trigo, Diogo, Jack, Julian, Corcoran, Jonathan P.T.
Publicado 2019

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

por Goncalves, Maria B., Wu, Yue, Trigo, Diogo, Clarke, Earl, Malmqvist, Tony, Grist, John, Hobbs, Carl, Carlstedt, Thomas P., Corcoran, Jonathan P.T.
Publicado 2018

RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

por Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Publicado 2019

Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury

por Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Barret Kalindjian, S., Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado 2019

Corrigendum to “Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury” [Bioorg. Med. Chem. Lett. 2...

por Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher I., Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado 2019

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

por Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado 2018