Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells

por König, Saskia, Fliegauf, Manfred, Rhiel, Manuel, Grimbacher, Bodo, Cornu, Tatjana I., Cathomen, Toni, Mussolino, Claudio
Publicado 2022

T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds

por Rhiel, Manuel, Geiger, Kerstin, Andrieux, Geoffroy, Rositzka, Julia, Boerries, Melanie, Cathomen, Toni, Cornu, Tatjana I.
Publicado 2023

Cell-Based Models of ‘Cytokine Release Syndrome’ Endorse CD40L and Granulocyte–Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Stra...

por Dibas, Ala, Rhiel, Manuel, Patel, Vidisha Bhavesh, Andrieux, Geoffroy, Boerries, Melanie, Cornu, Tatjana I., Alzubi, Jamal, Cathomen, Toni
Publicado 2023

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion

por Şöllü, Cem, Pars, Kaweh, Cornu, Tatjana I., Thibodeau-Beganny, Stacey, Maeder, Morgan L., Joung, J. Keith, Heilbronn, Regine, Cathomen, Toni
Publicado 2010

Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells

por Mlambo, Tafadzwa, Nitsch, Sandra, Hildenbeutel, Markus, Romito, Marianna, Müller, Maximilian, Bossen, Claudia, Diederichs, Sven, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Publicado 2018

A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells

por Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Publicado 2023

Automated generation of gene-edited CAR T cells at clinical scale

por Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Publicado 2020

Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

por Marone, Romina, Landmann, Emmanuelle, Devaux, Anna, Lepore, Rosalba, Seyres, Denis, Zuin, Jessica, Burgold, Thomas, Engdahl, Corinne, Capoferri, Giuseppina, Dell’Aglio, Alessandro, Larrue, Clément, Simonetta, Federico, Rositzka, Julia, Rhiel, Manuel, Andrieux, Geoffroy, Gallagher, Danielle N., Schröder, Markus S., Wiederkehr, Amélie, Sinopoli, Alessandro, Do Sacramento, Valentin, Haydn, Anna, Garcia-Prat, Laura, Divsalar, Christopher, Camus, Anna, Xu, Liwen, Bordoli, Lorenza, Schwede, Torsten, Porteus, Matthew, Tamburini, Jérôme, Corn, Jacob E., Cathomen, Toni, Cornu, Tatjana I., Urlinger, Stefanie, Jeker, Lukas T.
Publicado 2023