Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

por Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.
Publicado 2016

KRAS is vulnerable to reversible switch-II pocket engagement in cells

por Vasta, James D., Peacock, D. Matthew, Zheng, Qinheng, Walker, Joel A., Zhang, Ziyang, Zimprich, Chad A., Thomas, Morgan R., Beck, Michael T., Binkowski, Brock F., Corona, Cesear R., Robers, Matthew B., Shokat, Kevan M.
Publicado 2022

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

por Schwalm, Martin P., Berger, Lena M., Meuter, Maximilian N., Vasta, James D., Corona, Cesear R., Röhm, Sandra, Berger, Benedict-Tilman, Farges, Frederic, Beinert, Sebastian M., Preuss, Franziska, Morasch, Viktoria, Rogov, Vladimir V., Mathea, Sebastian, Saxena, Krishna, Robers, Matthew B., Müller, Susanne, Knapp, Stefan
Publicado 2022

Quantifying CDK inhibitor selectivity in live cells

por Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.
Publicado 2020

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

por Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.
Publicado 2018

Discovery of a selective inhibitor of Doublecortin Like Kinase 1

por Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.
Publicado 2020