Cation–π interactions in protein–ligand binding: theory and data-mining reveal different roles for lysine and arginine

por Kumar, Kiran, Woo, Shin M., Siu, Thomas, Cortopassi, Wilian A., Duarte, Fernanda, Paton, Robert S.
Publicado 2018

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity

por Aguiar, Anna C.C., Murce, Erika, Cortopassi, Wilian A., Pimentel, Andre S., Almeida, Maria M.F.S., Barros, Daniele C.S., Guedes, Jéssica S., Meneghetti, Mario R., Krettli, Antoniana U.
Publicado 2018

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

por Butler, Victoria J., Gao, Fuying, Corrales, Christian I., Cortopassi, Wilian A., Caballero, Benjamin, Vohra, Mihir, Ashrafi, Kaveh, Cuervo, Ana Maria, Jacobson, Matthew P., Coppola, Giovanni, Kao, Aimee W.
Publicado 2019

Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum

por Cortopassi, Wilian A., Penna-Coutinho, Julia, Aguiar, Anna C. C., Pimentel, André S., Buarque, Camilla D., Costa, Paulo R. R., Alves, Bruna R. M., França, Tanos C. C., Krettli, Antoniana U.
Publicado 2014

Synthesis of the Ca(2+)-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

por Lin, Wee K., Bolton, Emma L., Cortopassi, Wilian A., Wang, Yanwen, O'Brien, Fiona, Maciejewska, Matylda, Jacobson, Matthew P., Garnham, Clive, Ruas, Margarida, Parrington, John, Lei, Ming, Sitsapesan, Rebecca, Galione, Antony, Terrar, Derek A.
Publicado 2017

Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues

por Cortopassi, Wilian A., Gunderson, Emma, Annunciato, Yasmin, Silva, Antony.E.S., dos Santos Ferreira, Amália, Garcia Teles, Carolina Bioni, Pimentel, Andre S., Ramamoorthi, Roopa, Gazarini, Marcos L, Meneghetti, Mario R., Guido, Rafael.V.C., Pereira, Dhelio B., Jacobson, Matthew P., Krettli, Antoniana U., Caroline C Aguiar, Anna
Publicado 2022

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

por Pliotas, Christos, Grayer, Samuel C., Ekkerman, Silvia, Chan, Anthony K. N., Healy, Jess, Marius, Phedra, Bartlett, Wendy, Khan, Amjad, Cortopassi, Wilian A., Chandler, Shane A., Rasmussen, Tim, Benesch, Justin L. P., Paton, Robert S., Claridge, Timothy D. W., Miller, Samantha, Booth, Ian R., Naismith, James H., Conway, Stuart J.
Publicado 2017

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

por Rooney, Timothy P C, Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A, Hay, Duncan A, Martin, Sarah, Tumber, Anthony, Rogers, Catherine M, Philpott, Martin, Wang, Minghua, Thompson, Amber L, Heightman, Tom D, Pryde, David C, Cook, Andrew, Paton, Robert S, Müller, Susanne, Knapp, Stefan, Brennan, Paul E, Conway, Stuart J
Publicado 2014

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain

por Brand, Michael, Clayton, James, Moroglu, Mustafa, Schiedel, Matthias, Picaud, Sarah, Bluck, Joseph P., Skwarska, Anna, Bolland, Hannah, Chan, Anthony K. N., Laurin, Corentine M. C., Scorah, Amy R., See, Larissa, Rooney, Timothy P. C., Andrews, Katrina H., Fedorov, Oleg, Perell, Gabriella, Kalra, Prakriti, Vinh, Kayla B., Cortopassi, Wilian A., Heitel, Pascal, Christensen, Kirsten E., Cooper, Richard I., Paton, Robert S., Pomerantz, William C. K., Biggin, Philip C., Hammond, Ester M., Filippakopoulos, Panagis, Conway, Stuart J.
Publicado 2021