Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

por Herath, Ananda, Cosford, Nicholas D P
Publicado 2017

Chapter 26 The Molecular Libraries Screening Center Network (MLSCN): Identifying Chemical Probes of Biological Systems

por Huryn, Donna M., Cosford, Nicholas D.P.
Publicado 2007

Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

por Limpert, Allison S, Mattmann, Margrith E, Cosford, Nicholas D P
Publicado 2013

Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins

por Finlay, Darren, Teriete, Peter, Vamos, Mitchell, Cosford, Nicholas D. P., Vuori, Kristiina
Publicado 2017

Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.

por Sharma, Vandana, Ichikawa, Mie, He, Ping, Scott, David A., Bravo, Yalda, Dahl, Russell, Ng, Bobby G., Cosford, Nicholas D. P., Freeze, Hudson H.
Publicado 2011

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

por Poksay, Karen S., Sheffler, Douglas J., Spilman, Patricia, Campagna, Jesus, Jagodzinska, Barbara, Descamps, Olivier, Gorostiza, Olivia, Matalis, Alex, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D. P., John, Varghese
Publicado 2017

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

por Wang, Huabo, Teriete, Peter, Hu, Angela, Raveendra-Panickar, Dhanya, Pendelton, Kelsey, Lazo, John S., Eiseman, Julie, Holien, Toril, Misund, Kristine, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Cosford, Nicholas D. P, Sundan, Anders, Prochownik, Edward V.
Publicado 2015

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

por Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J., Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C., Cosford, Nicholas D. P.
Publicado 2016

Benzodiazepinone Derivatives Protect against Endoplasmic Reticulum Stress-Mediated Cell Death in Human Neuronal Cell Lines

por Zou, Haixia, Limpert, Allison S., Zou, Jiwen, Dembo, Anna, Lee, Pooi-San, Grant, Daniel, Ardecky, Robert, Pinkerton, Anthony B., Magnuson, Gavin K., Goldman, Mark E., Rong, Juan, Teriete, Peter, Sheffler, Douglas J., Reed, John C., Cosford, Nicholas D. P.
Publicado 2014

Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype-2 and -3 (mGlu(2/3)) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and...

por Dhanya, Raveendra-Panickar, Sheffler, Douglas J., Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P., Smith, Layton H., D’Souza, Manoranjan S., Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P.
Publicado 2014

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

por Pache, Lars, Marsden, Matthew D., Teriete, Peter, Portillo, Alex J., Heimann, Dominik, Kim, Jocelyn T., Soliman, Mohamed S.A., Dimapasoc, Melanie, Carmona, Camille, Celeridad, Maria, Spivak, Adam M., Planelles, Vicente, Cosford, Nicholas D.P., Zack, Jerome A., Chanda, Sumit K.
Publicado 2020

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

por Haass-Koffler, Carolina L., Chase Francis, T., Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., Sheffler, Douglas J.
Publicado 2022

Synthesis and preliminary studies of (11)C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2

por Zhang, Xiaofei, Zhang, Yiding, Chen, Zhen, Shao, Tuo, Van, Richard, Kumata, Katsushi, Deng, Xiaoyun, Fu, Hualong, Yamasaki, Tomoteru, Rong, Jian, Hu, Kuan, Hatori, Akiko, Xie, Lin, Yu, Qingzhen, Ye, Weijian, Xu, Hao, Sheffler, Douglas J., Cosford, Nicholas D. P., Shao, Yihan, Tang, Pingping, Wang, Lu, Zhang, Ming-Rong, Liang, Steven H.
Publicado 2020

Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells

por Raveendra-Panickar, Dhanya, Finlay, Darren, Layng, Fabiana Izidro, Lambert, Lester J., Celeridad, Maria, Zhao, Ming, Barbosa, Karina, De Backer, Laurent J.S., Kwong, Elizabeth, Gosalia, Palak, Rodiles, Socorro, Holleran, John, Ardecky, Robert, Grotegut, Stefan, Olson, Steven, Hutchinson, John H., Pasquale, Elena B., Vuori, Kristiina, Deshpande, Aniruddha J., Cosford, Nicholas D.P., Tautz, Lutz
Publicado 2021

Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

por Yue, Peibin, Zhu, Yinsong, Brotherton-Pleiss, Christine, Fu, Wenzhen, Verma, Nagendra, Chen, Jasmine, Nakamura, Kayo, Chen, Weiliang, Chen, Yue, Alonso-Valenteen, Felix, Mikhael, Simoun, Medina-Kauwe, Lali, Kershaw, Kathleen M., Celeridad, Maria, Pan, Songqin, Limpert, Allison S., Sheffler, Douglas J., Cosford, Nicholas D. P., Shiao, Stephen L., Tius, Marcus A., Lopez-Tapia, Francisco, Turkson, James
Publicado 2022