In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols

por Cossar, Peter J., Baker, Jennifer R., Cain, Nicholas, McCluskey, Adam
Publicado 2018

Covalent flexible peptide docking in Rosetta

por Tivon, Barr, Gabizon, Ronen, Somsen, Bente A., Cossar, Peter J., Ottmann, Christian, London, Nir
Publicado 2021

Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions

por Cossar, Peter J., Wolter, Madita, van Dijck, Lars, Valenti, Dario, Levy, Laura M., Ottmann, Christian, Brunsveld, Luc
Publicado 2021

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

por Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2023

Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry

por Verhoef, Carlo J. A., Kay, Danielle F., van Dijck, Lars, Doveston, Richard G., Brunsveld, Luc, Leney, Aneika C., Cossar, Peter J.
Publicado 2023

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

por Somsen, Bente A., Sijbesma, Eline, Leysen, Seppe, Honzejkova, Karolina, Visser, Emira J., Cossar, Peter J., Obšil, Tomáš, Brunsveld, Luc, Ottmann, Christian
Publicado 2023

A simple method for developing lysine targeted covalent protein reagents

por Gabizon, Ronen, Tivon, Barr, Reddi, Rambabu N., van den Oetelaar, Maxime C. M., Amartely, Hadar, Cossar, Peter J., Ottmann, Christian, London, Nir
Publicado 2023

Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

por Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Publicado 2020

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach

por Wolter, Madita, Valenti, Dario, Cossar, Peter J., Hristeva, Stanimira, Levy, Laura M., Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Publicado 2021

Amino Alcohols as Potential Antibiotic and Antifungal Leads

por Baker, Jennifer R., Cossar, Peter J., Blaskovich, Mark A. T., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Lewis, Peter J., McCluskey, Adam
Publicado 2022

Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity

por Cossar, Peter J., Abdel-Hamid, Mohammed K., Ma, Cong, Sakoff, Jennette A., Trinh, Trieu N., Gordon, Christopher P., Lewis, Peter J., McCluskey, Adam
Publicado 2017

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

por Somsen, Bente A., Craenmehr, Fenna W. B., Liu, Wei-Hong W., Koops, Auke A., Pennings, Marloes A. M., Visser, Emira J., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2022

Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

por Meijer, Femke A., Saris, Annet O.W.M., Doveston, Richard G., Oerlemans, Guido J.M., de Vries, Rens M.J.M., Somsen, Bente A., Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2021