Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

por Cossins, Benjamin P., Lawson, Alastair D. G.
Publicado 2015

A New View of the Bacterial Cytosol Environment

por Cossins, Benjamin P., Jacobson, Matthew P., Guallar, Victor
Publicado 2011

Deconstructing allostery by computational assessment of the binding determinants of allosteric PTP1B modulators

por Hardie, Adele, Cossins, Benjamin P., Lovera, Silvia, Michel, Julien
Publicado 2023

Combining Machine Learning and Enhanced Sampling Techniques for Efficient and Accurate Calculation of Absolute Binding Free Energies

por Evans, Rhys, Hovan, Ladislav, Tribello, Gareth A., Cossins, Benjamin P., Estarellas, Carolina, Gervasio, Francesco L.
Publicado 2020

Open Binding Pose Metadynamics: An Effective Approach for the Ranking of Protein–Ligand Binding Poses

por Lukauskis, Dominykas, Samways, Marley L., Aureli, Simone, Cossins, Benjamin P., Taylor, Richard D., Gervasio, Francesco Luigi
Publicado 2022

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR

por Amos, Sarah-Beth T. A., Schwarz, Thomas C., Shi, Jiye, Cossins, Benjamin P., Baker, Terry S., Taylor, Richard J., Konrat, Robert, Sansom, Mark S. P.
Publicado 2021

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab

por Davies, Anna M., Allan, Elizabeth G., Keeble, Anthony H., Delgado, Jean, Cossins, Benjamin P., Mitropoulou, Alkistis N., Pang, Marie O. Y., Ceska, Tom, Beavil, Andrew J., Craggs, Graham, Westwood, Marta, Henry, Alistair J., McDonnell, James M., Sutton, Brian J.
Publicado 2017

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

por O’Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel, McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox III, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair
Publicado 2019