Health economics: the start of clinical freedom

por Sacristán, José Antonio, Costi, María, Valladares, Amparo, Dilla, Tatiana
Publicado 2010

Clinical characteristics of patients with type 2 diabetes mellitus at the time of insulin initiation: INSTIGATE observational study in Spain

por Costi , María, Dilla, Tatiana, Reviriego, Jesús, Castell, Conxa, Goday, Albert
Publicado 2009

Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology

por Borsari, Chiara, Trader, Darci J., Tait, Annalisa, Costi, Maria P.
Publicado 2020

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

por Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

por Pozzi, Cecilia, Lopresti, Ludovica, Santucci, Matteo, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Healthcare Costs Associated with Change in Body Mass Index in Patients with Type 2 Diabetes Mellitus in Spain: The ECOBIM Study

por Dilla, Tatiana, Valladares, Amparo, Nicolay, Claudia, Salvador, Javier, Reviriego, Jesús, Costi, María
Publicado 2012

Permeation through the Cell Membrane of a Boron-Based β-Lactamase Inhibitor

por Minozzi, Manuela, Lattanzi, Gianluca, Benz, Roland, Costi, Maria P., Venturelli, Alberto, Carloni, Paolo
Publicado 2011

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Va...

por Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Tassone, Giusy, Costi, Maria Paola, Mangani, Stefano
Publicado 2019

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

por Possart, Katharina, Herrmann, Fabian C., Jose, Joachim, Costi, Maria P., Schmidt, Thomas J.
Publicado 2021

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

por Tondi, Donatella, Venturelli, Alberto, Bonnet, Richard, Pozzi, Cecilia, Shoichet, Brian K., Costi, Maria Paola
Publicado 2014

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I

por Herrmann, Fabian C., Sivakumar, Nirina, Jose, Joachim, Costi, Maria P., Pozzi, Cecilia, Schmidt, Thomas J.
Publicado 2017

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

por Francesconi, Valeria, Giovannini, Luca, Santucci, Matteo, Cichero, Elena, Costi, Maria Paola, Naesens, Lieve, Giordanetto, Fabrizio, Tonelli, Michele
Publicado 2018

The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human O...

por Marverti, Gaetano, Gozzi, Gaia, Lauriola, Angela, Ponterini, Glauco, Belluti, Silvia, Imbriano, Carol, Costi, Maria Paola, D’Arca, Domenico
Publicado 2019

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity

por Realini, Natalia, Solorzano, Carlos, Pagliuca, Chiara, Pizzirani, Daniela, Armirotti, Andrea, Luciani, Rosaria, Costi, Maria Paola, Bandiera, Tiziano, Piomelli, Daniele
Publicado 2013

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

por Tonelli, Michele, Naesens, Lieve, Gazzarrini, Sabrina, Santucci, Matteo, Cichero, Elena, Tasso, Bruno, Moroni, Anna, Costi, Maria Paola, Loddo, Roberta
Publicado 2017

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

por Tassone, Giusy, Landi, Giacomo, Linciano, Pasquale, Francesconi, Valeria, Tonelli, Michele, Tagliazucchi, Lorenzo, Costi, Maria Paola, Mangani, Stefano, Pozzi, Cecilia
Publicado 2021

Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective

por Pozzi, Cecilia, Vanet, Anne, Francesconi, Valeria, Tagliazucchi, Lorenzo, Tassone, Giusy, Venturelli, Alberto, Spyrakis, Francesca, Mazzorana, Marco, Costi, Maria P., Tonelli, Michele
Publicado 2023

Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isola...

por Tagliazucchi, Lorenzo, Perea-Martinez, Ana, Fiorini, Greta, Manzano, José Ignacio, Genovese, Filippo, García-Hernández, Raquel, Pinetti, Diego, Gamarro, Francisco, Costi, Maria Paola
Publicado 2023

Repurposing of Drugs Targeting YAP-TEAD Functions

por Elisi, Gian Marco, Santucci, Matteo, D’Arca, Domenico, Lauriola, Angela, Marverti, Gaetano, Losi, Lorena, Scalvini, Laura, Bolognesi, Maria Laura, Mor, Marco, Costi, Maria Paola
Publicado 2018

Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

por Pacifico, Salvatore, Santucci, Matteo, Luciani, Rosaria, Saxena, Puneet, Linciano, Pasquale, Ponterini, Glauco, Lauriola, Angela, D’Arca, Domenico, Marverti, Gaetano, Guerrini, Remo, Costi, Maria Paola
Publicado 2019