Chemical Space Exploration of Oxetanes

por Alves, Fernando Rodrigues de Sá, Couñago, Rafael M., Laufer, Stefan
Publicado 2020

Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames)

por Couñago, Rafael M, Davlieva, Milya, Strych, Ulrich, Hill, Ryan E, Krause, Kurt L
Publicado 2009

Evolution of the B3 DNA Binding Superfamily: New Insights into REM Family Gene Diversification

por Romanel, Elisson A. C., Schrago, Carlos G., Couñago, Rafael M., Russo, Claudia A. M., Alves-Ferreira, Márcio
Publicado 2009

Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment

por Aquino, Bruno, Couñago, Rafael M., Verza, Natalia, Ferreira, Lucas M., Massirer, Katlin B., Gileadi, Opher, Arruda, Paulo
Publicado 2017

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

por Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G., Kobe, Bostjan
Publicado 2016

A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells

por Cunha, Micael R., Catta-Preta, Carolina M.C., Takarada, Jéssica E., Moreira, Gabriela A., Massirer, Katlin B., Couñago, Rafael M.
Publicado 2023

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

por Santiago, André da Silva, Couñago, Rafael M., Ramos, Priscila Zonzini, Godoi, Paulo H. C., Massirer, Katlin B., Gileadi, Opher, Elkins, Jonathan M.
Publicado 2018

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity

por Righetto, Germanna Lima, Sriranganadane, Dev, Halabelian, Levon, Chiodi, Carla G., Elkins, Jonathan M., Massirer, Katlin B., Gileadi, Opher, Menossi, Marcelo, Couñago, Rafael M.
Publicado 2019

Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major

por Silva, Suélen Fernandes, Klippel, Angélica Hollunder, Ramos, Priscila Zonzini, Santiago, André da Silva, Valentini, Sandro Roberto, Bengtson, Mario Henrique, Massirer, Katlin Brauer, Bilsland, Elizabeth, Couñago, Rafael Miguez, Zanelli, Cleslei Fernando
Publicado 2020

An open source plant kinase chemogenomics set

por Ercoli, Maria Florencia, Ramos, Priscila Zonzini, Jain, Rashmi, Pilotte, Joseph, Dong, Oliver Xiaoou, Thompson, Ty, Wells, Carrow I., Elkins, Jonathan M., Edwards, Aled M., Couñago, Rafael M., Drewry, David H., Ronald, Pamela C.
Publicado 2022

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors

por Asquith, Christopher R. M., Godoi, Paulo H., Couñago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.
Publicado 2018

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

por Couñago, Rafael M., Allerston, Charles K., Savitsky, Pavel, Azevedo, Hatylas, Godoi, Paulo H., Wells, Carrow I., Mascarello, Alessandra, de Souza Gama, Fernando H., Massirer, Katlin B., Zuercher, William J., Guimarães, Cristiano R. W., Gileadi, Opher
Publicado 2017

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

por O’Byrne, Sean N., Scott, John W., Pilotte, Joseph R., Santiago, André da S., Langendorf, Christopher G., Oakhill, Jonathan S., Eduful, Benjamin J., Couñago, Rafael M., Wells, Carrow I., Zuercher, William J., Willson, Timothy M., Drewry, David H.
Publicado 2020

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

por Begg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O’Mara, Megan L., Paton, James C., McDevitt, Christopher A.
Publicado 2015

Binding and structural analyses of potent inhibitors of the human Ca(2+)/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-availabl...

por Profeta, Gerson S., dos Reis, Caio V., Santiago, André da S., Godoi, Paulo H. C., Fala, Angela M., Wells, Carrow I., Sartori, Roger, Salmazo, Anita P. T., Ramos, Priscila Z., Massirer, Katlin B., Elkins, Jonathan M., Drewry, David H., Gileadi, Opher, Couñago, Rafael M.
Publicado 2019

Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in forkhead-associated regulatory domains

por Cabarca, Sindy, Frazão de Souza, Maximilia, Albert de Oliveira, Andrew, Vignoli Muniz, Gabriel S., Lamy, M. Teresa, Vinicius dos Reis, Caio, Takarada, Jessica, Effer, Brian, Souza, Lucas Santos, Iriarte de la Torre, Lilia, Couñago, Rafael, Pinto Oliveira, Cristiano Luis, Balan, Andrea
Publicado 2021

Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation

por Marcelino, Tiago de Paula, Fala, Angela Maria, da Silva, Matheus Monteiro, Souza-Melo, Normanda, Malvezzi, Amaranta Muniz, Klippel, Angélica Hollunder, Zoltner, Martin, Padilla-Mejia, Norma, Kosto, Samantha, Field, Mark C., Burle-Caldas, Gabriela de Assis, Teixeira, Santuza Maria Ribeiro, Couñago, Rafael Miguez, Massirer, Katlin Brauer, Schenkman, Sergio
Publicado 2023

Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2

por Serafim, Ricardo A. M., de Souza Gama, Fernando H., Dutra, Luiz A., dos Reis, Caio V., Vasconcelos, Stanley N. S., da Silva Santiago, André, Takarada, Jéssica E., Di Pillo, Fúlvia, Azevedo, Hatylas, Mascarello, Alessandra, Elkins, Jonathan M., Massirer, Katlin B., Gileadi, Opher, Guimarães, Cristiano R. W., Couñago, Rafael M.
Publicado 2019

SGC-CAMKK2-1: A Chemical Probe for CAMKK2

por Wells, Carrow, Liang, Yi, Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Eduful, Benjamin, O’Byrne, Sean, Hossain, Mohammad Anwar, Catta-Preta, Carolina Moura Costa, Ramos, Priscila Zonzini, Gileadi, Opher, Gileadi, Carina, Couñago, Rafael M., Stork, Brittany, Langendorf, Christopher G., Nay, Kevin, Oakhill, Jonathan S., Mukherjee, Debarati, Racioppi, Luigi, Means, Anthony R., York, Brian, McDonnell, Donald P., Scott, John W., Frigo, Daniel E., Drewry, David H.
Publicado 2023

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

por Eduful, Benjamin J., O’Byrne, Sean N., Temme, Louisa, Asquith, Christopher R. M., Liang, Yi, Picado, Alfredo, Pilotte, Joseph R., Hossain, Mohammad Anwar, Wells, Carrow I., Zuercher, William J., Catta-Preta, Carolina M. C., Zonzini Ramos, Priscila, Santiago, André de S., Couñago, Rafael M., Langendorf, Christopher G., Nay, Kévin, Oakhill, Jonathan S., Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Willson, Timothy M., Frigo, Daniel E., Scott, John W., Drewry, David H.
Publicado 2021