Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

por Coudrat, Thomas, Christopoulos, Arthur, Sexton, Patrick Michael, Wootten, Denise
Publicado 2017

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

por Coudrat, Thomas, Simms, John, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M.
Publicado 2017

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

por Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M., Miller, Laurence J.
Publicado 2021

The role of kinetic context in apparent biased agonism at GPCRs

por Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicado 2016

Phase-plate cryo-EM structure of a class B GPCR-G protein complex

por Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M.
Publicado 2017