Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

por Vinci, Maria, Gowan, Sharon, Boxall, Frances, Patterson, Lisa, Zimmermann, Miriam, Court, William, Lomas, Cara, Mendiola, Marta, Hardisson, David, Eccles, Suzanne A
Publicado 2012

Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice

por De Haven Brandon, Alexis, Box, Gary, Hallsworth, Albert, Court, William, Matthews, Nicoll, Herodek, Balint, Arteagabeitia, Aitor Bermejo, Valenti, Melanie, Kirkin, Vladimir
Publicado 2020

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

por Dart, Anna E., Box, Gary M., Court, William, Gale, Madeline E., Brown, John P., Pinder, Sarah E., Eccles, Suzanne A., Wells, Claire M.
Publicado 2015

Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro

por Burmi, Rajpal S., Box, Gary M., Wazir, Umar, Hussain, Haroon A., Davies, Julie A., Court, William J., Eccles, Suzanne A., Jiang, Wen G., Mokbel, Kefah, Harvey, Amanda J.
Publicado 2022

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

por Miranda, Elena, Nordgren, Ida K., Male, Abigail L., Lawrence, Charlotte E., Hoakwie, Franciane, Cuda, Francesco, Court, William, Fox, Keith R., Townsend, Paul A., Packham, Graham K., Eccles, Suzanne A., Tavassoli, Ali
Publicado 2013

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

por Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T., Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A., Eccles, Suzanne A., Stieber, Frank, Schiemann, Kai, Blagg, Julian
Publicado 2015