Protein sequence optimization with a pairwise decomposable penalty for buried unsatisfied hydrogen bonds

por Coventry, Brian, Baker, David
Publicado 2021

Randomized gates eliminate bias in sort‐seq assays

por Trippe, Brian L., Huang, Buwei, DeBenedictis, Erika A., Coventry, Brian, Bhattacharya, Nicholas, Yang, Kevin K., Baker, David, Crawford, Lorin
Publicado 2022

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

por Jeong, Bo-Seong, Cha, Jeong Seok, Hwang, Insu, Kim, Uijin, Adolf-Bryfogle, Jared, Coventry, Brian, Cho, Hyun-Soo, Kim, Kyun-Do, Oh, Byung-Ha
Publicado 2022

De novo design of protein homodimers containing tunable symmetric protein pockets

por Hicks, Derrick R., Kennedy, Madison A., Thompson, Kirsten A., DeWitt, Michelle, Coventry, Brian, Kang, Alex, Bera, Asim K., Brunette, T. J., Sankaran, Banumathi, Stoddard, Barry, Baker, David
Publicado 2022

Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins

por Gerben, Stacey R, Borst, Andrew J, Hicks, Derrick R, Moczygemba, Isabelle, Feldman, David, Coventry, Brian, Yang, Wei, Bera, Asim K., Miranda, Marcos, Kang, Alex, Nguyen, Hannah, Baker, David
Publicado 2023

Improving de novo protein binder design with deep learning

por Bennett, Nathaniel R., Coventry, Brian, Goreshnik, Inna, Huang, Buwei, Allen, Aza, Vafeados, Dionne, Peng, Ying Po, Dauparas, Justas, Baek, Minkyung, Stewart, Lance, DiMaio, Frank, De Munck, Steven, Savvides, Savvas N., Baker, David
Publicado 2023

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

por Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E., Carter, Lauren, Walls, Alexandra C., Park, Young-Jun, Strauch, Eva-Maria, Stewart, Lance, Diamond, Michael S., Veesler, David, Baker, David
Publicado 2020

De novo design of luciferases using deep learning

por Yeh, Andy Hsien-Wei, Norn, Christoffer, Kipnis, Yakov, Tischer, Doug, Pellock, Samuel J., Evans, Declan, Ma, Pengchen, Lee, Gyu Rie, Zhang, Jason Z., Anishchenko, Ivan, Coventry, Brian, Cao, Longxing, Dauparas, Justas, Halabiya, Samer, DeWitt, Michelle, Carter, Lauren, Houk, K. N., Baker, David
Publicado 2023

Computational design of sequence-specific DNA-binding proteins

por Glasscock, Cameron J., Pecoraro, Robert, McHugh, Ryan, Doyle, Lindsey A., Chen, Wei, Boivin, Olivier, Lonnquist, Beau, Na, Emily, Politanska, Yuliya, Haddox, Hugh K., Cox, David, Norn, Christoffer, Coventry, Brian, Goreshnik, Inna, Vafeados, Dionne, Lee, Gyu Rie, Gordan, Raluca, Stoddard, Barry L., DiMaio, Frank, Baker, David
Publicado 2023

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

por Edman, Natasha I, Redler, Rachel L, Phal, Ashish, Schlichthaerle, Thomas, Srivatsan, Sanjay R, Etemadi, Ali, An, Seong J, Favor, Andrew, Ehnes, Devon, Li, Zhe, Praetorius, Florian, Gordon, Max, Yang, Wei, Coventry, Brian, Hicks, Derrick R., Cao, Longxing, Bethel, Neville, Heine, Piper, Murray, Analisa, Gerben, Stacey, Carter, Lauren, Miranda, Marcos, Negahdari, Babak, Lee, Sangwon, Trapnell, Cole, Stewart, Lance, Ekiert, Damian C., Schlessinger, Joseph, Shendure, Jay, Bhabha, Gira, Ruohola-Baker, Hannele, Baker, David
Publicado 2023

Design of protein-binding proteins from the target structure alone

por Cao, Longxing, Coventry, Brian, Goreshnik, Inna, Huang, Buwei, Sheffler, William, Park, Joon Sung, Jude, Kevin M., Marković, Iva, Kadam, Rameshwar U., Verschueren, Koen H. G., Verstraete, Kenneth, Walsh, Scott Thomas Russell, Bennett, Nathaniel, Phal, Ashish, Yang, Aerin, Kozodoy, Lisa, DeWitt, Michelle, Picton, Lora, Miller, Lauren, Strauch, Eva-Maria, DeBouver, Nicholas D., Pires, Allison, Bera, Asim K., Halabiya, Samer, Hammerson, Bradley, Yang, Wei, Bernard, Steffen, Stewart, Lance, Wilson, Ian A., Ruohola-Baker, Hannele, Schlessinger, Joseph, Lee, Sangwon, Savvides, Savvas N., Garcia, K. Christopher, Baker, David
Publicado 2022

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation

por Huang, Buwei, Abedi, Mohamad, Ahn, Green, Coventry, Brian, Sappington, Isaac, Wang, Rong, Schlichthaerle, Thomas, Zhang, Jason Z., Wang, Yujia, Goreshnik, Inna, Chiu, Ching Wen, Chazin-Gray, Adam, Chan, Sidney, Gerben, Stacey, Murray, Analisa, Wang, Shunzhi, O’Neill, Jason, Yeh, Ronald, Misquith, Ayesha, Wolf, Anitra, Tomasovic, Luke M., Piraner, Dan I, Gonzalez, Maria J. Duran, Bennett, Nathaniel R., Venkatesh, Preetham, Satoe, Danny, Ahlrichs, Maggie, Dobbins, Craig, Yang, Wei, Wang, Xinru, Vafeados, Dionne, Mout, Rubul, Shivaei, Shirin, Cao, Longxing, Carter, Lauren, Stewart, Lance, Spangler, Jamie B., Bernardes, Gonçalo J.L., Roybal, Kole T., Greisen, Per, Li, Xiaochun, Bertozzi, Carolyn, Baker, David
Publicado 2023