The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host

por Lodge, Katharine M., Cowburn, Andrew S., Li, Wei, Condliffe, Alison M.
Publicado 2020

Cardiovascular adaptation to hypoxia and the role of peripheral resistance

por Cowburn, Andrew S, Macias, David, Summers, Charlotte, Chilvers, Edwin R, Johnson, Randall S
Publicado 2017

EPIDERMAL DELETION OF HIF-2α STIMULATES WOUND CLOSURE

por Cowburn, Andrew S., Crotty Alexander, Laura E., Southwood, Mark, Nizet, Victor, Chilvers, Edwin R., Johnson, Randall S.
Publicado 2013

HIF-2α is essential for carotid body development and function

por Macias, David, Cowburn, Andrew S, Torres-Torrelo, Hortensia, Ortega-Sáenz, Patricia, López-Barneo, José, Johnson, Randall S
Publicado 2018

Correction: HIF-2α is essential for carotid body development and function

por Macias, David, Cowburn, Andrew S, Torres-Torrelo, Hortensia, Ortega-Sáenz, Patricia, López-Barneo, José, Johnson, Randall
Publicado 2018

The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion

por Fiddler, Christine A., Parfrey, Helen, Cowburn, Andrew S., Luo, Ding, Nash, Gerard B., Murphy, Gillian, Chilvers, Edwin R.
Publicado 2016

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells

por Condliffe, Alison M, Cadwallader, Karen A, Walker, Trevor R, Rintoul, Robert C, Cowburn, Andrew S, Chilvers, Edwin R
Publicado 2000

Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors

por Lambden, Simon, Cowburn, Andrew S., Macias, David, Garrud, Tessa A. C., Krause, Bernardo J., Giussani, Dino A., Summers, Charlotte, Johnson, Randall S.
Publicado 2021

Human Cytomegalovirus Delays Neutrophil Apoptosis and Stimulates the Release of a Prosurvival Secretome

por Pocock, Joanna M., Storisteanu, Daniel M. L., Reeves, Matthew B., Juss, Jatinder K., Wills, Mark R., Cowburn, Andrew S., Chilvers, Edwin R.
Publicado 2017

Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension

por Macias, David, Moore, Stephen, Crosby, Alexi, Southwood, Mark, Du, Xinlin, Tan, Huiling, Xie, Shanhai, Vassallo, Arlette, Wood, Alexander J.T., Wallace, Eli M., Cowburn, Andrew S.
Publicado 2021

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

por Walmsley, Sarah R., Print, Cristin, Farahi, Neda, Peyssonnaux, Carole, Johnson, Randall S., Cramer, Thorsten, Sobolewski, Anastasia, Condliffe, Alison M., Cowburn, Andrew S., Johnson, Nicola, Chilvers, Edwin R.
Publicado 2005

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

por Ashmore, Tom, Fernandez, Bernadette O, Branco-Price, Cristina, West, James A, Cowburn, Andrew S, Heather, Lisa C, Griffin, Julian L, Johnson, Randall S, Feelisch, Martin, Murray, Andrew J
Publicado 2014

Caveolae protect endothelial cells from membrane rupture during increased cardiac output

por Cheng, Jade P.X., Mendoza-Topaz, Carolina, Howard, Gillian, Chadwick, Jessica, Shvets, Elena, Cowburn, Andrew S., Dunmore, Benjamin J., Crosby, Alexi, Morrell, Nicholas W., Nichols, Benjamin J.
Publicado 2015

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

por Juss, Jatinder K., Hayhoe, Richard P., Owen, Charles E., Bruce, Ian, Walmsley, Sarah R., Cowburn, Andrew S., Kulkarni, Suhasini, Boyle, Keith B., Stephens, Len, Hawkins, Phillip T., Chilvers, Edwin R., Condliffe, Alison M.
Publicado 2012

Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

por Prendecki, Maria, Gulati, Kavita, Pisacano, Noelle, Pinheiro, Damilola, Bhatt, Tejal, Mawhin, Marie‐Anne, Toulza, Frederic, Masuda, Esteban S., Cowburn, Andrew, Lodge, Katharine M., Tam, Frederick W. K., Roufosse, Candice, Pusey, Charles D., McAdoo, Stephen P.
Publicado 2022

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism

por Ashmore, Tom, Roberts, Lee D., Morash, Andrea J., Kotwica, Aleksandra O., Finnerty, John, West, James A., Murfitt, Steven A., Fernandez, Bernadette O., Branco, Cristina, Cowburn, Andrew S., Clarke, Kieran, Johnson, Randall S., Feelisch, Martin, Griffin, Julian L., Murray, Andrew J.
Publicado 2015

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

por Sim, Jingwei, Cowburn, Andrew S., Palazon, Asis, Madhu, Basetti, Tyrakis, Petros A., Macías, David, Bargiela, David M., Pietsch, Sandra, Gralla, Michael, Evans, Colin E., Kittipassorn, Thaksaon, Chey, Yu C.J., Branco, Cristina M., Rundqvist, Helene, Peet, Daniel J., Johnson, Randall S.
Publicado 2018

Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease

por Lodge, Katharine M., Vassallo, Arlette, Liu, Bin, Long, Merete, Tong, Zhen, Newby, Paul R., Agha-Jaffar, Danya, Paschalaki, Koralia, Green, Clara E., Belchamber, Kylie B. R., Ridger, Victoria C., Stockley, Robert A., Sapey, Elizabeth, Summers, Charlotte, Cowburn, Andrew S., Chilvers, Edwin R., Li, Wei, Condliffe, Alison M.
Publicado 2022

Neutrophil GM‐CSF receptor dynamics in acute lung injury

por De Alessandris, Silvia, Ferguson, G. John, Dodd, Alison J., Juss, Jatinder K., Devaprasad, Abhinandan, Piper, Siân, Wyatt, Owen, Killick, Helen, Corkill, Dominic J., Cohen, E. Suzanne, Pandit, Aridaman, Radstake, Timothy R.D.J., Simmonds, Rosalind, Condliffe, Alison M., Sleeman, Matthew A., Cowburn, Andrew S., Finch, Donna K., Chilvers, Edwin R.
Publicado 2019

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

por Semba, Hiroaki, Takeda, Norihiko, Isagawa, Takayuki, Sugiura, Yuki, Honda, Kurara, Wake, Masaki, Miyazawa, Hidenobu, Yamaguchi, Yoshifumi, Miura, Masayuki, Jenkins, Dana M. R., Choi, Hyunsung, Kim, Jung-whan, Asagiri, Masataka, Cowburn, Andrew S., Abe, Hajime, Soma, Katsura, Koyama, Katsuhiro, Katoh, Manami, Sayama, Keimon, Goda, Nobuhito, Johnson, Randall S., Manabe, Ichiro, Nagai, Ryozo, Komuro, Issei
Publicado 2016